TrkA

NTRK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS
Identifiers
Aliases	NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1
External IDs	OMIM: 191315 MGI: 97383 HomoloGene: 1898 GeneCards: NTRK1
Gene ontology Molecular function • neurotrophin binding • GPI-linked ephrin receptor activity • neurotrophin receptor activity • kinase activity • ATP binding • protein kinase activity • kinase binding • transferase activity • protein homodimerization activity • protein binding • nucleotide binding • nerve growth factor binding • neurotrophin p75 receptor binding • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • nerve growth factor receptor activity Cellular component • cytoplasm • endosome • membrane • late endosome membrane • cell surface • integral component of membrane • late endosome • early endosome membrane • receptor complex • plasma membrane • protein complex • axon • neuronal cell body • early endosome • integral component of plasma membrane • dendrite • cytoplasmic vesicle Biological process • negative regulation of neuron apoptotic process • positive regulation of protein phosphorylation • positive regulation of Ras protein signal transduction • positive regulation of programmed cell death • behavioral response to formalin induced pain • detection of temperature stimulus involved in sensory perception of pain • protein phosphorylation • circadian rhythm • positive regulation of ERK1 and ERK2 cascade • B cell differentiation • response to ethanol • innervation • negative regulation of cell proliferation • activation of MAPKK activity • response to nicotine • positive regulation of GTPase activity • positive regulation of synaptic transmission, glutamatergic • response to nutrient levels • learning or memory • protein autophosphorylation • negative regulation of neuron death • detection of mechanical stimulus involved in sensory perception of pain • cell differentiation • neurotrophin TRK receptor signaling pathway • phosphorylation • cellular response to nicotine • olfactory nerve development • response to electrical stimulus • Sertoli cell development • mechanoreceptor differentiation • nervous system development • positive regulation of angiogenesis • positive regulation of NF-kappaB transcription factor activity • response to axon injury • sensory perception of pain • response to radiation • phosphatidylinositol-mediated signaling • sympathetic nervous system development • ephrin receptor signaling pathway • cellular response to growth factor stimulus • aging • response to hydrostatic pressure • response to activity • axon guidance • multicellular organism development • axonogenesis involved in innervation • positive regulation of neuron projection development • response to drug • programmed cell death involved in cell development • positive regulation of synapse assembly • transmembrane receptor protein tyrosine kinase signaling pathway • microtubule-based movement • peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • nerve growth factor signaling pathway • cellular response to nerve growth factor stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4914	18211
Ensembl	ENSG00000198400	ENSMUSG00000028072
UniProt	P04629	Q3UFB7
RefSeq (mRNA)	NM_002529 NM_001007792 NM_001012331	NM_001033124
RefSeq (protein)	NP_001007793 NP_001012331 NP_002520	NP_001028296.1 NP_001028296
Location (UCSC)	Chr 1: 156.82 – 156.88 Mb	Chr 3: 87.78 – 87.8 Mb
PubMed search

1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS

4914

18211

ENSG00000198400

ENSMUSG00000028072

P04629

Q3UFB7

NM_002529
NM_001007792
NM_001012331

...
Wikipedia