The Tri-River Conference, established around 1965, was a seven-member IHSAA-sanctioned conference located within Clay, Greene, Morgan, and Sullivan counties in Indiana. It was named for the southern Eel, White, and Wabash rivers which flow through the territory of the conference. Clay City, , Shakamak, and Union (Dugger) high schools also participated in the Southwestern Indiana Conference at the same time. The conference disbanded at the end of the 2009-2010 school year.