Trestolone

Trestolone
Clinical data

ATC code	none
Identifiers
IUPAC name 17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
Synonyms	MENT; 7α-Methylnandrolone; 7α-methyl-19-nortestosterone; 17β-hydroxy-7α-methylestr-4-en-3-one
CAS Number	3764-87-2^N
PubChem (CID)	9838899
ChemSpider	8014619^N
UNII	40P3287I94^Y
ECHA InfoCard	100.184.887
Chemical and physical data
Formula	C₁₉H₂₈O₂
Molar mass	288.424 g/mol
3D model (Jmol)	Interactive image
SMILES O=C4\C=C2/[C@@H]([C@H]1CC[C@@]3([C@@H](O)CC[C@H]3[C@@H]1[C@H](C)C2)C)CC4
InChI InChI=1S/C19H28O2/c1-11-9-12-10-13(20)3-4-14(12)15-7-8-19(2)16(18(11)15)5-6-17(19)21/h10-11,14-18,21H,3-9H2,1-2H3/t11-,14+,15-,16+,17+,18-,19+/m1/s1^N Key:YSGQGNQWBLYHPE-CFUSNLFHSA-N^N
^NY (what is this?)

Trestolone (INN), also known as 7α-methyl-19-nortestosterone (MENT) or 7α-methylestr-4-en-17β-ol-3-one, is a synthetic androgenic-anabolic steroid (AAS). It is used to build muscle rapidly and is a theoretical candidate drug for use in hormonal male contraceptive methods. In males, regular administration of sufficient quantities of trestolone induces a reversible state of infertility. Trestolone is used as the acetate ester, trestolone acetate, which is administered via intramuscular injection and acts as a long-lasting prodrug of trestolone.

Trestolone is an experimental contraceptive treatment and is not yet available commercially. It is currently being evaluated for safety and effectiveness in scientific studies, supported by the Population Council.

As a derivative of the anabolic steroid hormone nandrolone (19-nortestosterone), trestolone's viability as a male contraceptive via spermatogenesis suppression is ten-fold in comparison to testosterone.

Spermatozoa are produced in the testes of males in a process called spermatogenesis. In order to render a man infertile, a hormone-based male contraceptive method must stop spermatogenesis by interrupting the release of gonadotropins from the pituitary gland. Even in low concentrations, trestolone is a potent inhibitor of the release of the gonadotropin hormones, luteinizing hormone (LH) and follicle stimulating hormone (FSH).

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