Translocator protein

TSPO
Identifiers
Aliases	TSPO, BPBS, BZRP, DBI, IBP, MBR, PBR, PBS, PKBS, PTBR, mDRC, pk18, translocator protein
External IDs	OMIM: 109610 MGI: 88222 HomoloGene: 574 GeneCards: TSPO
Targeted by Drug
pk-11195
Gene ontology Molecular function • ion channel binding • androgen binding • benzodiazepine receptor activity • cholesterol binding • protein binding Cellular component • mitochondrial outer membrane • mitochondrion • integral component of membrane • membrane • mitochondrial membrane • extracellular exosome Biological process • positive regulation of necrotic cell death • response to vitamin B1 • response to testosterone • negative regulation of glial cell proliferation • response to progesterone • negative regulation of ATP metabolic process • aging • regulation of steroid biosynthetic process • contact inhibition • cellular hypotonic response • negative regulation of mitochondrion organization • negative regulation of mitophagy • ion transport • adrenal gland development • cellular response to zinc ion • negative regulation of protein ubiquitination • maintenance of protein location in mitochondrion • positive regulation of reactive oxygen species metabolic process • negative regulation of nitric oxide biosynthetic process • behavioral response to pain • response to manganese ion • establishment of protein localization to mitochondrion • positive regulation of mitochondrial depolarization • peripheral nervous system axon regeneration • response to pain • response to axon injury • positive regulation of apoptotic process • negative regulation of tumor necrosis factor production • chloride transport • cellular response to lipopolysaccharide • positive regulation of glial cell proliferation • response to drug • glial cell migration • steroid biosynthetic process • positive regulation of calcium ion transport • signal transduction • steroid metabolic process • lipid transport • protein targeting to mitochondrion • anion transport • regulation of cholesterol transport • heme biosynthetic process • transport • cell proliferation • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	706	12257
Ensembl	ENSG00000100300	ENSMUSG00000041736
UniProt	P30536	P50637
RefSeq (mRNA)	NM_000714 NM_001256530 NM_001256531 NM_007311	NM_009775
RefSeq (protein)	NP_000705.2 NP_001243459.1 NP_001243460.1	NP_033905.3 NP_033905
Location (UCSC)	Chr 22: 43.15 – 43.16 Mb	Chr 15: 83.56 – 83.57 Mb
PubMed search

706

12257

ENSG00000100300

ENSMUSG00000041736

P30536

P50637

NM_000714
NM_001256530
NM_001256531
NM_007311

NM_009775

NP_000705.2
NP_001243459.1
NP_001243460.1

NP_033905.3
NP_033905

Translocator protein (TSPO) is an 18 kDa protein mainly found on the . It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the receptor to be expressed throughout the body and brain. In humans, the translocator protein is encoded by the TSPO gene. It belongs to family of tryptophan-rich sensory proteins. Regarding intramitochondrial cholesterol transport, TSPO has been proposed to interact with StAR (steroidogenic acute regulatory protein) to transport cholesterol into , though evidence is mixed.

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Wikipedia