Toxicology testing

Toxicology testing, also known as safety assessment, or toxicity testing, is conducted to determine the degree to which a substance can damage a living or non-living organisms. It is often conducted by researchers using standard test procedures to comply with governing regulations, for example for medicines and pesticides. Much toxicology is considered to be part of the field of preclinical development. Stages of in vitro and in vivo research are conducted to determine safe doses of exposure in humans before a first-in-man study. Toxicology testing may be conducted by the pharmaceutical industry, biotechnology companies or contract research organizations.

Around one million animals, primate and non–primate, are used every year in Europe in toxicology tests. In the UK, one-fifth of animal experiments are toxicology tests. Animal testing for cosmetic purposes is currently banned all across the European Union

Toxicity tests examine finished products such as pesticides, medications, cosmetics, food additives such as artificial sweeteners, packing materials, and air freshener, or their chemical ingredients. The substances are applied to the skin or eyes; injected intravenously, intramuscularly, or subcutaneously; inhaled either by placing a mask over the animals and restraining them, or by placing them in an inhalation chamber; or administered orally, through a tube into the stomach, or placing them in the animals' food. Doses may be given once, repeated regularly for many months, or for the lifespan of the animal. Toxicity tests can also be conducted on materials need to be disposed such as sediment to be disposed in marine environment.

A contract research organization (CRO) is an organization that provides support to the pharmaceutical, biotechnology, chemical, and medical device industries in the form of research services outsourced on a contract basis. A CRO may provide toxicity testing services, along with others such as assay development, preclinical research, clinical research, clinical trials management, and pharmacovigilance. CROs also support foundations, research institutions, and universities, in addition to governmental organizations (such as the NIH, EMEA, etc.).

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