Totonacapan refers to the historical extension where the Totonac people of Mexico dominated, as well as to a region in the modern states of Veracruz and Puebla. The historical territory was much larger than the currently named region, extending from the Cazones River in the north to the Papaloapan River in the south and then west from the Gulf of Mexico into what is now the Sierra Norte de Puebla region and into parts of Hidalgo. When the Spanish arrived, the Totonac ethnicity dominated this large region, although they themselves were dominated by the Aztec Empire. For this reason, they allied with Hernán Cortés against Tenochtitlán. However, over the colonial period, the Totonac population and territory shrank, especially after 1750 when mestizos began infiltrating Totonacapan, taking political and economic power. This continued into the 19th and 20th centuries, prompting the division of most of historical Totonacpan between the states of Puebla and Veracruz. Today, the term refers only to a region in the north of Veracruz were Totonac culture is still important. This region is home to the El Tajín and Cempoala archeological sites as well as Papantla, which is noted for its performance of the Danza de los Voladores.
The earliest human settlements in the area date back to about 2000 BCE with agriculture practiced early with those communities on the coast having seafood prominent in the diet, especially mollusks. The area thrived with many small villages and ceremonial center because of abundant agricultural production. The beginning of the Classic period around 300BCE brought great changes to the region as it became part of an important trade route between Teotihuacan and the Mayas. Evidence of Teotihuacan influence become evident including religion and architecture.