Torsemide

Torasemide

Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601212
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral, IV
ATC code	C03CA04 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Biological half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
IUPAC name N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
CAS Number	56211-40-6 Y
PubChem (CID)	41781
IUPHAR/BPS	7312
DrugBank	DB00214 Y
ChemSpider	38123 Y
UNII	W31X2H97FB Y
KEGG	D00382 Y
ChEBI	CHEBI:9637 N
ChEMBL	CHEMBL1148 Y
ECHA InfoCard	100.164.924
Chemical and physical data
Formula	C16H20N4O3S
Molar mass	348.421 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(=O)(c2c(Nc1cc(ccc1)C)ccnc2)NC(=O)NC(C)C
InChI InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) Y Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N Y
NY (what is this?)

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand names Demadex, Diuver, and Examide.

Compared with other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium loss. No evidence of torasemide-induced ototoxicity has been demonstrated in humans.

Recent publications suggest improved outcomes when used for heart failure compared with furosemide.