Titin

TTN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UOW, 1BPV, 1G1C, 1NCT, 1NCU, 1TIT, 1TIU, 1TKI, 1TNM, 1TNN, 1WAA, 1YA5, 2A38, 2BK8, 2F8V, 2ILL, 2J8H, 2J8O, 2NZI, 2RQ8, 2WP3, 2WWK, 2WWM, 2Y9R, 3KNB, 3LCY, 3LPW, 3PUC, 3Q5O, 3QP3, 4C4K, 4JNW, 4O00, 4QEG, 5BS0
Identifiers
Aliases	TTN, CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD, titin
External IDs	MGI: 98864 HomoloGene: 130650 GeneCards: TTN
Gene ontology Molecular function • transferase activity • nucleotide binding • calcium ion binding • protein kinase activity • actinin binding • muscle alpha-actinin binding • structural molecule activity conferring elasticity • metal ion binding • calmodulin binding • telethonin binding • protease binding • protein self-association • actin filament binding • protein serine/threonine kinase activity • kinase activity • protein binding • identical protein binding • enzyme binding • protein tyrosine kinase activity • structural constituent of muscle • ATP binding • protein kinase binding Cellular component • cytoplasm • cytosol • I band • striated muscle thin filament • condensed nuclear chromosome • extracellular region • Z disc • muscle myosin complex • extracellular exosome • nucleus • M band Biological process • sarcomerogenesis • muscle contraction • mitotic chromosome condensation • cardiac muscle contraction • phosphorylation • cardiac muscle hypertrophy • platelet degranulation • cardiac muscle tissue morphogenesis • skeletal muscle thin filament assembly • detection of muscle stretch • cardiac muscle fiber development • response to calcium ion • cardiac myofibril assembly • protein phosphorylation • muscle filament sliding • regulation of protein kinase activity • regulation of catalytic activity • sarcomere organization • skeletal muscle myosin thick filament assembly • striated muscle contraction • peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7273	22138
Ensembl	ENSG00000155657	ENSMUSG00000051747
UniProt	Q8WZ42	A2ASS6
RefSeq (mRNA)	NM_001256850 NM_001267550 NM_003319 NM_133378 NM_133379 NM_133432 NM_133437	NM_011652 NM_028004
RefSeq (protein)	NP_001243779 NP_001254479 NP_003310 NP_596869 NP_596870 NP_597676 NP_597681	NP_035782 NP_082280
Location (UCSC)	Chr 2: 23.57 – 178.83 Mb	Chr 2: 76.7 – 76.98 Mb
PubMed search

4UOW, 1BPV, 1G1C, 1NCT, 1NCU, 1TIT, 1TIU, 1TKI, 1TNM, 1TNN, 1WAA, 1YA5, 2A38, 2BK8, 2F8V, 2ILL, 2J8H, 2J8O, 2NZI, 2RQ8, 2WP3, 2WWK, 2WWM, 2Y9R, 3KNB, 3LCY, 3LPW, 3PUC, 3Q5O, 3QP3, 4C4K, 4JNW, 4O00, 4QEG, 5BS0

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