Tiletamine

Tiletamine

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	IV, IM, SC, Other
ATC code	none
Legal status
Legal status	AU: S4 (Prescription only) US: Schedule III
Pharmacokinetic data
Metabolism	Liver
Excretion	Kidneys
Identifiers
IUPAC name 2-ethylamino-2-(2-thienyl) cyclohexanone
CAS Number	14176-50-2 N
PubChem CID	26533
ChemSpider	24714 Y
UNII	2YFC543249
KEGG	D08596 Y
ECHA InfoCard	100.034.559
Chemical and physical data
Formula	C12H17NOS
Molar mass	223.34 g/mol
3D model (Jmol)	Interactive image
SMILES O=C2C(c1sccc1)(NCC)CCCC2
InChI InChI=1S/C12H17NOS/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14/h5,7,9,13H,2-4,6,8H2,1H3 Y Key:QAXBVGVYDCAVLV-UHFFFAOYSA-N Y
NY (what is this?)

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically to ketamine. Tiletamine hydrochloride exists as odourless white crystals.

It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as polar bears and wood bison. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.

Abuse of Telazol has been documented. Animal studies have also shown that tiletamine produces rewarding and reinforcing effects. Tiletamine products are classified as Schedule III controlled substances in the United States.