Thyroid hormone receptor alpha

THRA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX

Identifiers

Aliases

THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha

External IDs

MGI: 98742 HomoloGene: 37747 GeneCards: THRA

Gene ontology
Molecular function	• protein complex binding • transcription regulatory region sequence-specific DNA binding • protein binding • single-stranded RNA binding • zinc ion binding • chromatin DNA binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • steroid receptor RNA activator RNA binding • transcription factor binding • TBP-class protein binding • steroid hormone receptor activity • DNA binding • protein domain specific binding • sequence-specific DNA binding • metal ion binding • transcription regulatory region DNA binding • transcription factor activity, sequence-specific DNA binding • thyroid hormone receptor activity • thyroid hormone binding
Cellular component	• cytoplasm • nucleoplasm • nucleus • cytosol
Biological process	• regulation of transcription from RNA polymerase II promoter • response to cold • cytoplasmic sequestering of transcription factor • hormone-mediated signaling pathway • regulation of thyroid hormone mediated signaling pathway • thyroid gland development • regulation of transcription, DNA-templated • ossification • female courtship behavior • cartilage condensation • negative regulation of RNA polymerase II transcriptional preinitiation complex assembly • Type I pneumocyte differentiation • transcription, DNA-templated • steroid hormone mediated signaling pathway • transcription from RNA polymerase II promoter • regulation of lipid catabolic process • regulation of heart contraction • animal organ morphogenesis • positive regulation of female receptivity • learning or memory • regulation of myeloid cell apoptotic process • positive regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • erythrocyte differentiation • negative regulation of DNA-templated transcription, initiation • positive regulation of myotube differentiation • negative regulation of transcription, DNA-templated • intracellular receptor signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7067


21833

Ensembl


ENSG00000126351


ENSMUSG00000058756

UniProt


P10827


P63058

RefSeq (mRNA)


NM_199334 NM_001190918 NM_001190919 NM_003250


NM_178060 NM_001313983

RefSeq (protein)


NP_001177847 NP_001177848 NP_003241 NP_955366


NP_001300912.1 NP_835161.1 NP_001300912 NP_835161

Location (UCSC)

Chr 17: 40.06 – 40.09 Mb

Chr 11: 98.74 – 98.77 Mb

PubMed search

1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX

NM_199334
NM_001190918
NM_001190919
NM_003250

NM_178060
NM_001313983

NP_001177847
NP_001177848
NP_003241
NP_955366

...
Wikipedia