Thymidylate synthase

TYMS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YPV, 1JU6, 2RDA, 3EF9, 3ED7, 1HW3, 3EHI, 3GH0, 4JEF, 4O1X, 1HZW, 3EAW, 3OB7, 3EBU, 4KPW, 3EGY, 3EJL, 3N5G, 3N5E, 1HVY, 4GD7, 4G2O, 4H1I, 2ONB, 3H9K, 4GYH, 3HB8, 1I00, 3GG5, 4FGT, 2RD8, 3EDW, 4G6W, 1HW4, 3GH2, 4E28, 1JUJ, 4O1U, 4UP1, 5HS3,%%s1HW3, 1YPV, 4GD7, 2ONB
Identifiers
Aliases	TYMS, HST422, TMS, TS, thymidylate synthetase
External IDs	OMIM: 188350 MGI: 98878 HomoloGene: 834 GeneCards: TYMS
Gene ontology Molecular function • methyltransferase activity • transferase activity • nucleotide binding • protein homodimerization activity • folic acid binding • thymidylate synthase activity • drug binding • cofactor binding • mRNA binding Cellular component • cytoplasm • cytosol • membrane • nucleoplasm • mitochondrial matrix • nucleolus • mitochondrion • mitochondrial inner membrane • nucleus Biological process • response to cytokine • nucleotide biosynthetic process • DNA biosynthetic process • response to organic cyclic compound • response to progesterone • G1/S transition of mitotic cell cycle • tetrahydrofolate interconversion • aging • pyrimidine nucleoside biosynthetic process • response to glucocorticoid • immortalization of host cell by virus • regulation of transcription involved in G1/S transition of mitotic cell cycle • dTTP biosynthetic process • tetrahydrofolate metabolic process • response to vitamin A • cell growth • cartilage development • methylation • developmental growth • response to organophosphorus • circadian rhythm • uracil metabolic process • dTMP biosynthetic process • intestinal epithelial cell maturation • dUMP metabolic process • response to folic acid • response to ethanol • cell proliferation • response to toxic substance • response to drug • pyrimidine nucleobase metabolic process • regulation of translation • liver regeneration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7298	22171
Ensembl	ENSG00000176890	ENSMUSG00000025747
UniProt	P04818 Q53Y97	P07607
RefSeq (mRNA)	NM_001071	NM_021288
RefSeq (protein)	NP_001062 NP_001062.1	NP_067263.1 NP_067263
Location (UCSC)	Chr 18: 0.66 – 0.67 Mb	Chr 5: 30.06 – 30.07 Mb
PubMed search

thymidylate synthase
Identifiers
EC number	2.1.1.45
CAS number	9031-61-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
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PMC	articles
PubMed	articles
NCBI	proteins

Thymidylate synthase
Identifiers
Symbol	Thymidylat_synt
Pfam	PF00303
InterPro	IPR000398
PROSITE	PDOC00086
SCOP	1tys
SUPERFAMILY	1tys
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

1YPV, 1JU6, 2RDA, 3EF9, 3ED7, 1HW3, 3EHI, 3GH0, 4JEF, 4O1X, 1HZW, 3EAW, 3OB7, 3EBU, 4KPW, 3EGY, 3EJL, 3N5G, 3N5E, 1HVY, 4GD7, 4G2O, 4H1I, 2ONB, 3H9K, 4GYH, 3HB8, 1I00, 3GG5, 4FGT, 2RD8, 3EDW, 4G6W, 1HW4, 3GH2, 4E28, 1JUJ, 4O1U, 4UP1, 5HS3,%%s1HW3, 1YPV, 4GD7, 2ONB

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