Thymidine kinase 1

TK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W4R, 1XBT, 2ORV, 2WVJ
Identifiers
Aliases	TK1, TK2, Thymidine kinase 1
External IDs	MGI: 98763 HomoloGene: 37749 GeneCards: TK1
Gene location (Human) Chr. Chromosome 17 (human) Band No data available Start 78,174,075 bp End 78,187,233 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band No data available Start 117,815,526 bp End 117,826,092 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • nucleoside kinase activity • zinc ion binding • metal ion binding • kinase activity • protein binding • identical protein binding • ATP binding • thymidine kinase activity Cellular component • cytoplasm • cytosol Biological process • DNA biosynthetic process • phosphorylation • pyrimidine nucleoside salvage • nucleobase-containing compound metabolic process • protein homotetramerization • deoxyribonucleoside monophosphate biosynthetic process • DNA metabolic process • nucleotide biosynthetic process • thymidine metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7083	21877
Ensembl	ENSG00000167900	ENSMUSG00000025574
UniProt	P04183	P04184
RefSeq (mRNA)	NM_003258 NM_001346663	NM_001271729 NM_009387
RefSeq (protein)	NP_001333592 NP_003249	NP_001258658 NP_033413
Location (UCSC)	Chr 17: 78.17 – 78.19 Mb	Chr 17: 117.82 – 117.83 Mb
PubMed search

1W4R, 1XBT, 2ORV, 2WVJ

7083

21877

ENSG00000167900

ENSMUSG00000025574

P04183

P04184

NM_003258
NM_001346663

NM_001271729
NM_009387

NP_001333592
NP_003249

NP_001258658
NP_033413

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase.

Two forms of this protein have been identified in animal cells, one in cytosol and one in . Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

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