Thromboxane-A synthase

TBXAS1
Identifiers
Aliases	TBXAS1, BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS, thromboxane A synthase 1
External IDs	OMIM: 274180 MGI: 98497 HomoloGene: 130979 GeneCards: TBXAS1
Genetically Related Diseases
amyotrophic lateral sclerosis, obesity,
Gene ontology Molecular function • iron ion binding • isomerase activity • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • 12-hydroxyheptadecatrienoic acid synthase activity • thromboxane-A synthase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • prostaglandin metabolic process • lipid metabolic process • icosanoid metabolic process • cyclooxygenase pathway • fatty acid metabolic process • fatty acid biosynthetic process • prostaglandin biosynthetic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6916	21391
Ensembl	ENSG00000059377	ENSMUSG00000029925
UniProt	P24557	P36423
RefSeq (mRNA)	NM_001314028 NM_001061 NM_001130966 NM_001166253 NM_001166254 NM_030984	NM_011539
RefSeq (protein)	NP_001052 NP_001124438 NP_001159725 NP_001159726 NP_001300957 NP_112246	NP_035669.3 NP_035669
Location (UCSC)	Chr 7: 139.78 – 140.02 Mb	Chr 6: 38.88 – 39.08 Mb
PubMed search

6916

21391

ENSG00000059377

ENSMUSG00000029925

P24557

P36423

NM_030984

NM_011539

NP_112246

NP_035669.3
NP_035669

Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A), also known as TBXAS1, is a enzyme that, in humans, is encoded by the TBXAS1 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H₂ to thromboxane A₂, a potent vasoconstrictor and inducer of platelet aggregation and 12-Hydroxyheptadecatrienoic acid (i.e. 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid or 12-HHT) and agonist of Leukotriene B4 receptors (i.e. BLT2 receptors) and mediator of certain BLT2 receptor]] actions. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants.

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Wikipedia