Thrombospondin-1

THBS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LSL, 1UX6, 1Z78, 1ZA4, 2ERF, 2ES3, 2OUH, 2OUJ, 3R6B, 5FOE
Identifiers
Aliases	THBS1, THBS, THBS-1, TSP, TSP-1, TSP1, thrombospondin 1
External IDs	MGI: 98737 HomoloGene: 31142 GeneCards: THBS1
Gene ontology Molecular function • calcium ion binding • heparin binding • glycoprotein binding • extracellular matrix binding • fibroblast growth factor binding • phosphatidylserine binding • proteoglycan binding • collagen V binding • fibrinogen binding • low-density lipoprotein particle binding • integrin binding • protein binding • laminin binding • fibronectin binding • identical protein binding • transforming growth factor beta binding Cellular component • endoplasmic reticulum lumen • extracellular region • platelet alpha granule • cell surface • endoplasmic reticulum • extracellular exosome • extracellular matrix • secretory granule • platelet alpha granule lumen • fibrinogen complex • sarcoplasmic reticulum • external side of plasma membrane • cytoplasm • extracellular space Biological process • positive regulation of transforming growth factor beta receptor signaling pathway • cellular response to heat • negative regulation of fibrinolysis • protein O-linked fucosylation • response to progesterone • response to magnesium ion • positive regulation of translation • negative regulation of endothelial cell migration • negative regulation of cell-matrix adhesion • negative regulation of plasma membrane long-chain fatty acid transport • positive regulation of reactive oxygen species metabolic process • positive regulation of blood coagulation • positive regulation of blood vessel endothelial cell migration • positive regulation of macrophage chemotaxis • positive regulation of protein kinase B signaling • negative regulation of plasminogen activation • negative regulation of blood vessel endothelial cell migration • negative regulation of extrinsic apoptotic signaling pathway • response to endoplasmic reticulum stress • positive regulation of endothelial cell apoptotic process • response to unfolded protein • positive regulation of chemotaxis • negative regulation of cGMP-mediated signaling • positive regulation of phosphorylation • inflammatory response • negative regulation of focal adhesion assembly • chronic inflammatory response • negative regulation of nitric oxide mediated signal transduction • regulation of cGMP metabolic process • positive regulation of tumor necrosis factor biosynthetic process • engulfment of apoptotic cell • extracellular matrix organization • positive regulation of macrophage activation • sprouting angiogenesis • negative regulation of apoptotic process • response to glucose • positive regulation of angiogenesis • response to calcium ion • positive regulation of transforming growth factor beta1 production • cell adhesion • activation of MAPK activity • behavioral response to pain • immune response • negative regulation of interleukin-12 production • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to hypoxia • positive regulation of cell migration • platelet degranulation • negative regulation of endothelial cell chemotaxis • negative regulation of endothelial cell proliferation • positive regulation of endothelial cell migration • negative regulation of fibroblast growth factor receptor signaling pathway • peptide cross-linking • negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • cell cycle arrest • negative regulation of dendritic cell antigen processing and presentation • negative regulation of angiogenesis • cell migration • positive regulation of fibroblast migration • response to drug • response to testosterone • cellular response to tumor necrosis factor • cellular response to growth factor stimulus • positive regulation of transforming growth factor beta production • response to mechanical stimulus • positive regulation of cell proliferation • positive regulation of smooth muscle cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7057	21825
Ensembl	ENSG00000137801	ENSMUSG00000040152
UniProt	P07996	P35441
RefSeq (mRNA)	NM_003246	NM_011580 NM_001313914
RefSeq (protein)	NP_003237	n/a
Location (UCSC)	Chr 15: 39.58 – 39.6 Mb	Chr 2: 118.11 – 118.13 Mb
PubMed search

1LSL, 1UX6, 1Z78, 1ZA4, 2ERF, 2ES3, 2OUH, 2OUJ, 3R6B, 5FOE

7057

21825

ENSG00000137801

ENSMUSG00000040152

P07996

P35441

NM_003246

NM_011580
NM_001313914

NP_003237

n/a

Thrombospondin 1, also known as THBS1, is a protein that in humans is encoded by the THBS1 gene.

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