Thomas Maria Mamachi (December 4, 1713 in Chios – June 7, 1792 in Corneto, near Montefiascone), was an Italo-Greek Dominican theologian and historian.
At the age of sixteen he entered the convent of Chios and passed later to St. Mark's at Florence and the Minerva at Rome.
In 1740 he was appointed professor of physics in the Roman Sapienza university, and in 1743 taught philosophy at the Propaganda Fide. His residence at Florence and Rome brought him into contact with brilliant men of his order, e.g. Giuseppe Agostino Orsi, Divelli and Daniello Concina, and greatly facilitated his progress in his studies. He collaborated with Orsi in his "De Romani pontificis in synodos oecumenicas et earum canones potestate".
Soon pope Benedict XIV appointed him prefect of the Casanatensian Library, master of theology and consultor of the Congregation of the Index. Owing to his office he had to take part in the controversy between the Appellants (Jansenists) and the Jesuits, and displayed an impartiality which greatly increased the difficulties of his anxious and laborious position. He engaged in lively theological controversies with Gian Domenico Mansi and Cadonici.
He had likewise to intervene in the controversy concerning the beatification of Juan de Palafox y Mendoza. In a published writing on this question, he dealt severely with the Jesuit party who opposed the beatification; but he was not less energetic in dealing with their opponents, the Appellants and Jansenist Church of Utrecht.