Thioredoxin

TXN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4TRX, 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK, 2IFQ, 2IIY, 3E3E, 3KD0, 3M9J, 3M9K, 3QFA, 3QFB, 3TRX, 4LL1, 4LL4, 4OO4, 4OO5, 4POK, 4POL, 4POM, 4PUF, 5DQY
Identifiers
Aliases	TXN, TRDX, TRX, TRX1, thioredoxin
External IDs	OMIM: 187700 MGI: 98874 HomoloGene: 128202 GeneCards: TXN
Gene ontology Molecular function • protein disulfide oxidoreductase activity • peptide disulfide oxidoreductase activity • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor • protein binding • thioredoxin-disulfide reductase activity • protein-disulfide reductase activity • RNA binding Cellular component • extracellular region • extracellular exosome • nucleus • cytoplasm • mitochondrion • cytosol Biological process • activation of protein kinase B activity • positive regulation of protein kinase B signaling • movement of cell or subcellular component • nucleobase-containing small molecule interconversion • glycerol ether metabolic process • regulation of transcription, DNA-templated • response to reactive oxygen species • cell-cell signaling • negative regulation of transcription from RNA polymerase II promoter • regulation of protein import into nucleus, translocation • cell redox homeostasis • transcription, DNA-templated • positive regulation of peptidyl-serine phosphorylation • negative regulation of protein export from nucleus • response to radiation • positive regulation of DNA binding • negative regulation of hydrogen peroxide-induced cell death • cell proliferation • oxidation-reduction process • signal transduction • protein repair • cellular oxidant detoxification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7295	22166
Ensembl	ENSG00000136810	ENSMUSG00000028367
UniProt	P10599	P10639
RefSeq (mRNA)	NM_003329 NM_001244938	NM_011660
RefSeq (protein)	NP_001231867 NP_003320	NP_035790.1 NP_035790
Location (UCSC)	Chr 9: 110.24 – 110.26 Mb	Chr 4: 57.94 – 57.96 Mb
PubMed search

4TRX, 1AIU, 1AUC, 1CQG, 1CQH, 1ERT, 1ERU, 1ERV, 1ERW, 1MDI, 1MDJ, 1MDK, 1TRS, 1TRU, 1TRV, 1TRW, 2HSH, 2HXK, 2IFQ, 2IIY, 3E3E, 3KD0, 3M9J, 3M9K, 3QFA, 3QFB, 3TRX, 4LL1, 4LL4, 4OO4, 4OO5, 4POK, 4POL, 4POM, 4PUF, 5DQY

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