Thiamylal

Thiamylal
Clinical data

AHFS/Drugs.com	International Drug Names
ATCvet code	QN01AF90 (WHO)
Legal status
Legal status	CA: Schedule IV US: Schedule III
Pharmacokinetic data
Metabolism	Hepatic
Biological half-life	14.3 h (cats)
Identifiers
IUPAC name 5-(Pentan-2-yl)-5-(prop-2-en-1-yl)-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione
Synonyms	Thiamylal, Thioseconal, Surital
CAS Number	77-27-0^Y
PubChem CID	3032285
IUPHAR/BPS	7305
DrugBank	DB01154^Y
ChemSpider	2297298^Y
UNII	01T23W89FR
KEGG	D06106^Y
ChEBI	CHEBI:9536^Y
ChEMBL	CHEMBL440^Y
ECHA InfoCard	100.000.927
Chemical and physical data
Formula	C₁₂H₁₈N₂O₂S
Molar mass	254.35 g/mol
3D model (Jmol)	Interactive image
SMILES O=C1NC(=S)NC(=O)C1(C(C)CCC)C\C=C
InChI InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)^Y Key:XLOMZPUITCYLMJ-UHFFFAOYSA-N^Y

Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgical anaesthesia or as an anticonvulsant to counteract side effects from other anaesthetics. It is the thiobarbiturate analogue of secobarbital.

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