Therapeutic hypothermia
| Targeted temperature management | |
|---|---|
| Intervention | |
| ICD-10-PCS | [1] |
| MeSH | C18.452.394.750 |
| OPS-301 code | 8-607 |
Targeted temperature management (TTM) previously known as therapeutic hypothermia or protective hypothermia is active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes during recovery after a period of stopped blood flow to the brain. This is done in an attempt to reduce the risk of tissue injury following lack of blood flow. Periods of poor blood flow may be due to cardiac arrest or the blockage of an artery by a clot as in the case of a stroke.
Targeted temperature management improves survival and brain function following resuscitation from cardiac arrest. Evidence supports its use following certain types of cardiac arrest in which an individual does not regain consciousness. Both 33 °C (91 °F) and 36 °C (97 °F) appear to result in similar outcomes. Targeted temperature management following traumatic brain injury has shown mixed results with some studies showing benefits in survival and brain function while others show no clear benefit. While associated with some complications, these are generally mild.
Targeted temperature management is thought to prevent brain injury by several methods including decreasing the brain's oxygen demand, reducing the production of neurotransmitters like glutamate, as well as reducing free radicals that might damage the brain. The lowering of body temperature may be accomplished by many means including the use of cooling blankets, cooling helmets, cooling catheters, ice packs and ice water lavage.
Targeted temperature management maybe used in the following conditions:
The 2013 ILCOR and 2010 American Heart Association guidelines support the use of cooling following resuscitation from cardiac arrest. These recommendations were largely based on two trials from 2002 which showed improved survival and brain function when cooled between 32 °C (90 °F) to 34 °C (93 °F) after cardiac arrest.
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