""The Take Over, the Breaks Over"" (rendered with quotation marks as part of its title on the album track listing) is a song by American rock band Fall Out Boy and the fourth single from their third studio album Infinity on High (2007). The song impacted radio on August 7, 2007. The music composition was inspired by vocalist and guitarist Patrick Stump's love of David Bowie, specifically the song "Rebel Rebel"; the lyrics were penned by bassist Pete Wentz. The song's title is a reference to Jay-Z's 2001 song "Takeover". The single found its greatest success in Australia, peaking at No. 17 on the singles chart there and finishing at No. 90 on the year-end chart.

The song's music video won a Canadian MuchMusic Video Award for People's Choice: Favorite International Video, beating Flo Rida, Kanye West, Rihanna, and Timbaland. It was also nominated for Best International Video – Group at the ceremony but lost to Linkin Park's "Bleed It Out".

""The Take Over, the Breaks Over"" features two guitar solos performed by guest guitarists Ryan Ross (formerly from Panic! at the Disco) and Chad Gilbert (from New Found Glory).

It was also released as a 7" vinyl in countries including the UK.

The song is featured on the Nintendo DS game, Guitar Hero: On Tour Decades. It is also featured as a downloadable song for Guitar Hero 5.

For the music, vocalist/guitarist Patrick Stump undertook his usual role as the band's primary composer.

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