Clinical data | |
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Pronunciation | /tɛˈstɒstəroʊn ənˈdɛkənoʊ.eɪt/ tess-TOSS-tə-rohn ən-DEK-ə-noh-ayt |
Trade names | Nebido, Aveed, Andriol, others |
Synonyms | Testosterone undecylate; 17β-[(1-Oxoundecyl)oxy]-androst-4-en-3-one |
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Routes of administration |
By mouth, intramuscular injection |
Drug class | Androgen; Anabolic steroid; Androgen ester |
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Pharmacokinetic data | |
Bioavailability |
Oral: 3–7% Intramuscular: ~100% |
Metabolism | Liver |
Biological half-life |
Tea seed oil: 20.9 days (i.m.) Castor oil: 33.9 days (i.m.) |
Excretion | Urine |
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ChEMBL | |
ECHA InfoCard | 100.025.193 |
Chemical and physical data | |
Formula | C30H48O3 |
Molar mass | 456.711 g/mol |
3D model (JSmol) | |
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(what is this?) |
Testosterone undecanoate, sold under the brand names Nebido, Aveed, and Andriol among others, is an androgen and anabolic steroid. It is used in androgen replacement therapy primarily for the treatment of male hypogonadism, and has also been investigated for use as a male contraceptive or as hormone replacement therapy in transgender men. It is a synthetic androgen ester which acts as a prodrug of testosterone, and hence is considered to be a natural and bioidentical form of testosterone. Unlike other testosterone esters, testosterone undecanoate is available in both oral and intramuscular formulations. As an intramuscular injection, it is much longer-acting than most other testosterone esters. Along with testosterone cypionate, testosterone enanthate, and testosterone propionate, testosterone undecanoate is one of the most widely used testosterone esters.
Testosterone undecanoate is used in androgen replacement therapy. As an intramuscular injection, it is administered at a dosage of 1,000 mg once every 12 weeks. The oral formulation of testosterone undecanoate must be taken two or three times a day with food.