Tenoxicam
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| AHFS/Drugs.com | International Drug Names |
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Oral |
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| Pharmacokinetic data | |
| Protein binding | High |
| Biological half-life | 30–140 hours |
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| ECHA InfoCard | 100.149.365 |
| Chemical and physical data | |
| Formula | C13H11N3O4S2 |
| Molar mass | 337.376 g/mol |
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Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID). It was originated by Roche but as of 2008 is sold by Meda AB under the trade name Mobiflex. It is available as a prescription-only drug in the United Kingdom and other countries, but not in the US. Outside of the United Kingdom, tenoxicam is also marketed under brand names including Tilatil, Tilcitin, and Alganex. Tenoxicam belongs to the class of NSAIDs known as oxicams. It is used to relieve inflammation, swelling, stiffness, and pain associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (a type of arthritis involving the spine), tendinitis (inflammation of a tendon), bursitis (inflammation of a bursa, a fluid-filled sac located around joints and near the bones), and periarthritis of the shoulders or hips (inflammation of tissues surrounding these joints).
Like all non-steroidal anti-inflammatory drugs, the exact mechanism of action of tenoxicam in unknown. Involved in the mechanism of action is inhibition of cyclooxygenase (COX-1 and COX-2) which leads to the potential adverse effect of increased bleeding.
The drug is contraindicated for patients who are seniors who have been given anesthesia or surgery; are at risk of increased bleeding or kidney failure; have an active inflammatory disease involving the stomach or intestine (like ulcerative colitis); have an active stomach or intestinal ulcer; have had an acute asthmatic attack, hives, rhinitis (inflammation of the inner lining of the nasal passage), or other allergic reactions caused by Aspirin or other nonsteroidal anti-inflammatory drugs (for example diclofenac, ibuprofen, indomethacin, naproxen).
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