Tenascin C

TNC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TEN, 2RB8, 2RBL
Identifiers
Aliases	TNC, 150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C, Tenascin C
External IDs	MGI: 101922 HomoloGene: 55636 GeneCards: TNC
Genetically Related Diseases
prostate cancer
Gene ontology Molecular function • syndecan binding Cellular component • interstitial matrix • membrane • focal adhesion • extracellular matrix • proteinaceous extracellular matrix • extracellular region • basement membrane • extracellular space Biological process • cellular response to retinoic acid • negative regulation of cell adhesion • bud outgrowth involved in lung branching • mesenchymal-epithelial cell signaling involved in prostate gland development • response to fibroblast growth factor • response to mechanical stimulus • extracellular matrix organization • wound healing • cellular response to vitamin D • odontogenesis of dentin-containing tooth • positive regulation of gene expression • cell adhesion • prostate gland epithelium morphogenesis • cellular response to prostaglandin D stimulus • regulation of cell proliferation • neuromuscular junction development • response to wounding • peripheral nervous system axon regeneration • osteoblast differentiation • positive regulation of cell proliferation • response to ethanol • neuron projection development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3371	21923
Ensembl	ENSG00000041982	ENSMUSG00000028364
UniProt	P24821	Q80YX1
RefSeq (mRNA)	NM_002160	NM_011607
RefSeq (protein)	NP_002151	NP_035737.2 NP_035737
Location (UCSC)	Chr 9: 115.02 – 115.12 Mb	Chr 4: 63.96 – 64.05 Mb
PubMed search

1TEN, 2RB8, 2RBL

3371

21923

ENSG00000041982

ENSMUSG00000028364

P24821

Q80YX1

NM_002160

NM_011607

NP_002151

NP_035737.2
NP_035737

Tenascin C (TN-C) is a glycoprotein that in humans is encoded by the TNC gene. It is expressed in the extracellular matrix of various tissues during development, disease or injury, and in restricted neurogenic areas of the central nervous system. Tenascin-C is the founding member of the tenascin protein family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage.

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Wikipedia