Telomerase reverse transcriptase

TERT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BCK, 4B18, 4MNQ
Identifiers
Aliases	TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase
External IDs	OMIM: 187270 MGI: 1202709 HomoloGene: 31141 GeneCards: TERT
Genetically Related Diseases
breast cancer, interstitial lung disease, adenocarcinoma of the lung, prostate cancer, lung cancer, , idiopathic pulmonary fibrosis, malignant glioma
Gene ontology Molecular function • transferase activity • DNA binding • nucleotidyltransferase activity • telomeric DNA binding • tRNA binding • metal ion binding • RNA-directed DNA polymerase activity • RNA-directed 5'-3' RNA polymerase activity • telomerase RNA reverse transcriptase activity • protein binding • RNA binding • transcription coactivator binding • telomerase RNA binding • telomerase activity • protein homodimerization activity • chaperone binding Cellular component • cytoplasm • PML body • nuclear telomere cap complex • RNA-directed RNA polymerase complex • intracellular ribonucleoprotein complex • nucleoplasm • chromosome • chromosome, telomeric region • telomerase catalytic core complex • nucleolus • mitochondrion • telomerase holoenzyme complex • TERT-RMRP complex • mitochondrial nucleoid • nuclear chromosome, telomeric region • nucleus • plasma membrane Biological process • positive regulation of protein localization to nucleolus • telomere maintenance via telomerase • DNA biosynthetic process • regulation of protein stability • replicative senescence • RNA-dependent DNA biosynthetic process • mitochondrion organization • positive regulation of hair cycle • negative regulation of gene expression • transcription, RNA-templated • positive regulation of Wnt signaling pathway • production of siRNA involved in RNA interference • positive regulation of nitric-oxide synthase activity • establishment of protein localization to telomere • negative regulation of production of siRNA involved in RNA interference • DNA strand elongation • positive regulation of protein binding • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • telomere maintenance • RNA biosynthetic process • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • positive regulation of stem cell proliferation • negative regulation of cellular senescence • response to cadmium ion • positive regulation of G1/S transition of mitotic cell cycle • beta-catenin-TCF complex assembly • negative regulation of apoptotic process • positive regulation of glucose import • positive regulation of angiogenesis • positive regulation of vascular associated smooth muscle cell migration • negative regulation of glial cell proliferation • positive regulation of transdifferentiation • cellular response to hypoxia • positive regulation of vascular smooth muscle cell proliferation • negative regulation of endothelial cell apoptotic process • negative regulation of neuron apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7015	21752
Ensembl	ENSG00000164362	ENSMUSG00000021611
UniProt	O14746	O70372
RefSeq (mRNA)	NM_001193376 NM_198253 NM_198254 NM_198255	NM_009354
RefSeq (protein)	NP_001180305 NP_937983	NP_033380.1 NP_033380
Location (UCSC)	Chr 5: 1.25 – 1.3 Mb	Chr 13: 73.63 – 73.65 Mb
PubMed search

2BCK, 4B18, 4MNQ

7015

21752

ENSG00000164362

ENSMUSG00000021611

O14746

O70372

NM_001193376
NM_198253
NM_198254
NM_198255

NM_009354

NP_001180305
NP_937983

NP_033380.1
NP_033380

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

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