Telenzepine

Telenzepine

Clinical data
ATC code	None
Identifiers
IUPAC name 1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one
CAS Number	80880-90-6
PubChem CID	5387
ChemSpider	5194
UNII	0990EG3K10
ChEMBL	CHEMBL253978
Chemical and physical data
Formula	C19H22N4O2S
Molar mass	370.47 g/mol
3D model (Jmol)	Interactive image
SMILES C1CN(C)CCN1CC(=O)N2c3ccccc3NC(=O)c4csc(C)c42

Telenzepine is a thienobenzodiazepine acting as selective M₁ antimuscarinic. It is used in the treatment of peptic ulcers. Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis; in neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active as the (–)-isomer at muscarinic receptors in the rat cerebal cortex.