Tbx5

TBX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X6U, 2X6V, 4S0H, 5BQD
Identifiers
Aliases	TBX5, HOS, T-box 5
External IDs	MGI: 102541 HomoloGene: 160 GeneCards: TBX5
Gene ontology Molecular function • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor binding • protein binding • transcription factor activity, sequence-specific DNA binding • DNA binding Cellular component • cytoplasm • nucleoplasm • nucleus Biological process • pattern specification process • forelimb morphogenesis • ventricular cardiac muscle tissue development • regulation of transcription, DNA-templated • bundle of His development • lung development • endocardial cushion development • cardiac muscle cell differentiation • cell-cell signaling • transcription, DNA-templated • morphogenesis of an epithelium • atrial septum morphogenesis • multicellular organism development • negative regulation of cell migration • positive regulation of cardiac muscle cell proliferation • atrioventricular valve morphogenesis • cell migration involved in coronary vasculogenesis • embryonic limb morphogenesis • pericardium development • positive regulation of cardioblast differentiation • positive regulation of secondary heart field cardioblast proliferation • transcription initiation from RNA polymerase II promoter • negative regulation of cardiac muscle cell proliferation • regulation of execution phase of apoptosis • atrial septum development • embryonic forelimb morphogenesis • negative regulation of epithelial to mesenchymal transition • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • cardiac left ventricle formation • ventricular septum development • heart development • positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6910	21388
Ensembl	ENSG00000089225	ENSMUSG00000018263
UniProt	Q99593	P70326
RefSeq (mRNA)	NM_181486 NM_000192 NM_080717 NM_080718	NM_011537
RefSeq (protein)	NP_000183 NP_542448 NP_852259	NP_035667.1 NP_035667
Location (UCSC)	Chr 12: 114.35 – 114.41 Mb	Chr 5: 119.83 – 119.89 Mb
PubMed search

2X6U, 2X6V, 4S0H, 5BQD

6910

21388

ENSG00000089225

ENSMUSG00000018263

Q99593

P70326

NM_181486
NM_000192
NM_080717
NM_080718

NM_011537

NP_000183
NP_542448
NP_852259

NP_035667.1
NP_035667

T-box transcription factor TBX5 is a protein that in humans is encoded by the TBX5 gene.

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Wikipedia