Tau protein

MAPT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I8H, 4GLR, 2ON9, 3OVL, 4E0M, 4E0N, 4E0O, 4FL5, 4NP8, 2MZ7, 4TQE, 4Y5I, 4Y32, 5DMG, 4Y3B, 5HF3, 5E2W, 5E2V
Identifiers
Aliases	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule associated protein tau, Tau proteins
External IDs	OMIM: 157140 MGI: 97180 HomoloGene: 74962 GeneCards: MAPT
Genetically Related Diseases
interstitial lung disease, progressive supranuclear palsy, Parkinson's disease
Gene ontology Molecular function • apolipoprotein binding • SH3 domain binding • tubulin binding • protein binding • lipoprotein particle binding • enzyme binding • DNA binding • actin binding • microtubule binding • dynactin binding • receptor agonist activity • protein phosphatase 2A binding • Hsp90 protein binding Cellular component • cytoplasm • cell body • cell projection • nuclear periphery • growth cone • neurofibrillary tangle • plasma membrane • tubulin complex • dendrite • cytoplasmic ribonucleoprotein granule • cytoskeleton • nucleus • cytosol • microtubule • microtubule associated complex • membrane • nuclear speck • axon • somatodendritic compartment • neuronal cell body • axon cytoplasm Biological process • generation of neurons • regulation of autophagy • regulation of microtubule polymerization • positive regulation of microtubule polymerization • positive regulation of axon extension • microtubule cytoskeleton organization • microglial cell activation • activation of cysteine-type endopeptidase activity involved in apoptotic process • signal transduction • memory • negative regulation of mitochondrial membrane potential • axonal transport of mitochondrion • cytoplasmic microtubule organization • neuron projection development • positive regulation of superoxide anion generation • negative regulation of kinase activity • cellular response to heat • astrocyte activation • intracellular distribution of mitochondria • synapse organization • regulation of calcium-mediated signaling • protein oligomerization • plus-end-directed organelle transport along microtubule • regulation of mitochondrial fission • negative regulation of mitochondrial fission • axonal transport • regulation of cellular response to heat • positive regulation of neuron death • positive regulation of protein localization to synapse • neurofibrillary tangle assembly • negative regulation of establishment of protein localization to mitochondrion • positive regulation of diacylglycerol kinase activity • regulation of response to DNA damage stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4137	17762
Ensembl	n/a	ENSMUSG00000018411
UniProt	P10636	P10637
RefSeq (mRNA)	NM_001123066 NM_001123067 NM_001203251 NM_001203252 NM_005910 NM_016834 NM_016835 NM_016841	NM_001038609 NM_010838 NM_001285454 NM_001285455 NM_001285456
RefSeq (protein)	NP_001116538 NP_001116539 NP_001190180 NP_001190181 NP_005901 NP_058518 NP_058519 NP_058525	NP_001033698.1 NP_001272383.1 NP_001272384.1 NP_001272385.1 NP_034968.3 NP_001033698 NP_001272383 NP_001272384 NP_001272385 NP_034968
Location (UCSC)	Chr 17: 45.89 – 46.03 Mb	Chr 11: 104.23 – 104.33 Mb
PubMed search

1I8H, 4GLR, 2ON9, 3OVL, 4E0M, 4E0N, 4E0O, 4FL5, 4NP8, 2MZ7, 4TQE, 4Y5I, 4Y32, 5DMG, 4Y3B, 5HF3, 5E2W, 5E2V

4137

17762

n/a

ENSMUSG00000018411

P10636

P10637

NM_016834
NM_016835
NM_016841

...
Wikipedia