Tapasin

TAPBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3F8U
Identifiers
Aliases	TAPBP, NGS17, TAPA, TPN, TPSN, TAP binding protein (tapasin), TAP binding protein
External IDs	OMIM: 601962 MGI: 1201689 HomoloGene: 2401 GeneCards: TAPBP
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 33,299,694 bp End 33,314,387 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band n/a Start 33,915,899 bp End 33,929,288 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptide antigen binding • TAP2 binding • unfolded protein binding • peptide antigen-transporting ATPase activity • protein binding • MHC class I protein binding • TAP1 binding Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • Golgi membrane • TAP complex • MHC class I peptide loading complex • endoplasmic reticulum • integral component of lumenal side of endoplasmic reticulum membrane • phagocytic vesicle membrane • endoplasmic reticulum-Golgi intermediate compartment membrane Biological process • retrograde vesicle-mediated transport, Golgi to ER • protein complex assembly • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of endogenous peptide antigen via MHC class I • regulation of protein complex stability • immune response • peptide antigen stabilization • regulation of gene expression • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane • peptide transport • amide transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6892	21356
Ensembl	ENSG00000231925 ENSG00000236490 ENSG00000206281 ENSG00000206208 ENSG00000112493 n/a	ENSMUSG00000024308
UniProt	O15533	Q9R233
RefSeq (mRNA)	NM_003190 NM_172208 NM_172209	NM_001025313 NM_009318
RefSeq (protein)	NP_003181 NP_757345 NP_757346	NP_001020484 NP_033344
Location (UCSC)	Chr 6: 33.3 – 33.31 Mb	Chr 6: 33.92 – 33.93 Mb
PubMed search

3F8U

6892

21356

n/a

ENSMUSG00000024308

O15533

Q9R233

NM_003190
NM_172208
NM_172209

NM_001025313
NM_009318

NP_003181
NP_757345
NP_757346

NP_001020484
NP_033344

TAP-associated glycoprotein also known as tapasin or TAPBP is a protein that in humans is encoded by the TAPBP gene.

This gene encodes a transmembrane glycoprotein that mediates interaction between newly assembled major histocompatibility complex () class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction facilitates optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and tapasin may be bound to a single TAP molecule. Tapasin contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. In humans, the tapasin gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.

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