Tamm–Horsfall protein

UMOD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WRN
Identifiers
Aliases	UMOD, ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP, uromodulin
External IDs	OMIM: 191845 MGI: 102674 HomoloGene: 2522 GeneCards: UMOD
Gene ontology Molecular function • calcium ion binding • IgG binding • extracellular matrix structural constituent Cellular component • cell projection • spindle pole • membrane • plasma membrane • extracellular region • basolateral plasma membrane • apical plasma membrane • ciliary membrane • anchored component of membrane • extracellular exosome • extrinsic component of membrane • Golgi lumen • cilium • proteinaceous extracellular matrix Biological process • leukocyte cell-cell adhesion • chemical homeostasis • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • excretion • metanephric distal convoluted tubule development • metanephric ascending thin limb development • cellular defense response • regulation of ion homeostasis • neutrophil migration • metanephric thick ascending limb development • negative regulation of cell proliferation • protein N-linked glycosylation via asparagine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7369	22242
Ensembl	ENSG00000169344	ENSMUSG00000030963
UniProt	P07911	Q91X17
RefSeq (mRNA)	NM_001008389 NM_001278614 NM_003361	NM_001278605 NM_009470
RefSeq (protein)	NP_001008390 NP_001265543 NP_003352	NP_001265534 NP_033496
Location (UCSC)	Chr 16: 20.33 – 20.36 Mb	Chr 7: 119.46 – 119.48 Mb
PubMed search

4WRN

7369

22242

ENSG00000169344

ENSMUSG00000030963

P07911

Q91X17

NM_001008389
NM_001278614
NM_003361

NM_001278605
NM_009470

NP_001008390
NP_001265543
NP_003352

NP_001265534
NP_033496

The Tamm–Horsfall glycoprotein (THP), also known as uromodulin, is a glycoprotein that in humans is encoded by the UMOD gene. Uromodulin is the most abundant protein excreted in ordinary urine.

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Wikipedia