Takatō Domain (高遠藩 Takatō-han?) was a feudal domain under the Tokugawa shogunate of Edo period Japan. It is located in Shinano Province, Honshū. The domain was centered at Takatō Castle, located in what is now part of the city of Ina in Nagano Prefecture.
The territory around Takatō was ruled during the Sengoku period by Takatō Yoritsugu (d. 1552). After his castle fell to Takeda Shingen in the Siege of Takatō in 1545, it was given over to one of Shingen's sons, Nishina Morinobu. Takatō then came under the control of Hoshina Masatoshi, a retainer of Tokugawa Ieyasu, following the defeat and subsequent destruction of the Takeda clan following the second Siege of Takatō in 1582.
Following the Battle of Sekigahara in 1600, and the establishment of the Tokugawa shogunate in 1603, Hoshina Masamitsu, the grandson of Masatoshi, became the first Edo period daimyō of Takatō, and the domain was officially ranked at a kokudaka of 25,000 koku. Masamitsu raised an illegitimate son of shogun Tokugawa Hidetada as his own, under the name Hoshina Masayuki, and was rewarded with a 5,000 koku increase for his domain in 1618. Following Hidetada's death in 1632, Masayuki was transferred to Yamagata Domain in Dewa Province in 1636, with an income of 200,000 koku.