TRPV4

TRPV4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DX1, 4DX2
Identifiers
Aliases	TRPV4, BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC, transient receptor potential cation channel subfamily V member 4
External IDs	OMIM: 605427 MGI: 1926945 HomoloGene: 11003 GeneCards: TRPV4
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.11 Start 109,783,085 bp End 109,833,401 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 114,622,152 bp End 114,658,421 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • stretch-activated, cation-selective, calcium channel activity • osmosensor activity • microtubule binding • alpha-tubulin binding • SH2 domain binding • calmodulin binding • actin filament binding • ion channel activity • protein binding • beta-tubulin binding • cation channel activity • actin binding • ATP binding • protein kinase binding • protein kinase C binding • calcium channel activity Cellular component • integral component of membrane • cell projection • membrane • focal adhesion • filopodium • growth cone • adherens junction • plasma membrane • ruffle membrane • cell surface • cell junction • apical plasma membrane • cortical actin cytoskeleton • cytoplasmic microtubule • cytoplasmic vesicle • lamellipodium • integral component of plasma membrane • Butt Biological process • actin cytoskeleton reorganization • cell volume homeostasis • cellular response to heat • positive regulation of inflammatory response • negative regulation of neuron projection development • signal transduction involved in regulation of aerobic respiration • positive regulation of interleukin-6 secretion • glucose homeostasis • cellular hypotonic salinity response • positive regulation of chemokine (C-X-C motif) ligand 1 production • positive regulation of cytosolic calcium ion concentration • calcium ion import • positive regulation of monocyte chemotactic protein-1 production • response to mechanical stimulus • negative regulation of brown fat cell differentiation • osmosensory signaling pathway • cellular calcium ion homeostasis • hyperosmotic salinity response • microtubule polymerization • negative regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • cellular hypotonic response • ion transport • vasopressin secretion • cellular response to osmotic stress • regulation of response to osmotic stress • diet induced thermogenesis • response to osmotic stress • response to insulin • positive regulation of gene expression • positive regulation of vascular permeability • calcium ion transmembrane transport • positive regulation of energy homeostasis • cortical microtubule organization • positive regulation of chemokine (C-C motif) ligand 5 production • cell-cell junction assembly • positive regulation of ERK1 and ERK2 cascade • transport • hypotonic response • positive regulation of macrophage inflammatory protein 1 alpha production • blood vessel endothelial cell delamination • multicellular organismal water homeostasis • positive regulation of macrophage chemotaxis • calcium ion transport • positive regulation of microtubule depolymerization • actin filament organization • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	59341	63873
Ensembl	ENSG00000111199	ENSMUSG00000014158
UniProt	Q9HBA0	Q9EPK8
RefSeq (mRNA)	NM_001177428 NM_001177431 NM_001177433 NM_021625 NM_147204	NM_022017
RefSeq (protein)	NP_001170899 NP_001170902 NP_001170904 NP_067638 NP_671737	NP_071300
Location (UCSC)	Chr 12: 109.78 – 109.83 Mb	Chr 12: 114.62 – 114.66 Mb
PubMed search

4DX1, 4DX2

59341

63873

ENSG00000111199

ENSMUSG00000014158

Q9HBA0

Q9EPK8

NM_001177428
NM_001177431
NM_001177433
NM_021625
NM_147204

NM_022017

NP_001170899
NP_001170902
NP_001170904
NP_067638
NP_671737

NP_071300

Transient receptor potential cation channel subfamily V member 4 is an ion channel protein that in humans is encoded by the TRPV4 gene.

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