TRPM2

TRPM2
Identifiers
Aliases	TRPM2, Trpm2, 9830168K16Rik, C79133, LTRPC2, TRPC7, Trp7, Trrp7, EREG1, KNP3, NUDT9H, NUDT9L1, LTrpC-2, transient receptor potential cation channel subfamily M member 2
External IDs	MGI: 1351901 HomoloGene: 20709 GeneCards: TRPM2
Gene ontology Molecular function • calcium channel activity • sodium channel activity • ion channel activity • cation channel activity • calcium ion binding • calcium-release channel activity • hydrolase activity • ligand-gated calcium channel activity Cellular component • integral component of membrane • membrane • plasma membrane • lysosome • lysosomal membrane • integral component of plasma membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • specific granule membrane • cell projection • perikaryon • tertiary granule membrane • ficolin-1-rich granule membrane Biological process • sodium ion transmembrane transport • sodium ion transport • cation transport • ion transport • response to oxidative stress • calcium ion transmembrane transport • calcium ion transport • ion transmembrane transport • transmembrane transport • temperature homeostasis • dendritic cell chemotaxis • response to purine-containing compound • calcium-mediated signaling using intracellular calcium source • neutrophil degranulation • release of sequestered calcium ion into cytosol • regulation of filopodium assembly • cellular response to hydrogen peroxide • cellular response to calcium ion • cellular response to purine-containing compound • cellular response to temperature stimulus • zinc II ion transmembrane transport • dendritic cell differentiation • calcium ion transmembrane import into cytosol • regulation of actin cytoskeleton reorganization • calcium ion import across plasma membrane • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7226	28240
Ensembl	ENSG00000142185	ENSMUSG00000009292
UniProt	O94759	Q91YD4
RefSeq (mRNA)	NM_001001188 NM_003307 NM_001320350 NM_001320351 NM_001320352	NM_138301
RefSeq (protein)	NP_001307279 NP_001307280 NP_001307281 NP_003298	NP_612174
Location (UCSC)	Chr 21: 44.35 – 44.44 Mb	Chr 10: 77.91 – 77.97 Mb
PubMed search

7226

28240

ENSG00000142185

ENSMUSG00000009292

O94759

Q91YD4

NM_001001188
NM_003307
NM_001320350
NM_001320351
NM_001320352

NM_138301

NP_001307279
NP_001307280
NP_001307281
NP_003298

NP_612174

Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.

The TRPM2 gene is highly expressed in the brain and was implicated by both genetic linkage studies in families and then by case control or trio allelic association studies in the genetic aetiology of bipolar affective disorder (Manic Depression).

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Wikipedia