TRPC1

TRPC1
Identifiers
Aliases	TRPC1, HTRP-1, TRP1, transient receptor potential cation channel subfamily C member 1
External IDs	OMIM: 602343 MGI: 109528 HomoloGene: 2478 GeneCards: TRPC1
Gene ontology Molecular function • store-operated calcium channel activity • ion channel binding • calcium channel activity • inositol 1,4,5 trisphosphate binding • ion channel activity • protein binding • cation channel activity Cellular component • integral component of membrane • membrane • receptor complex • plasma membrane • integral component of plasma membrane Biological process • melanin biosynthetic process • regulation of cardiac conduction • regulation of cytosolic calcium ion concentration • positive regulation of release of sequestered calcium ion into cytosol • ion transport • response to calcium ion • calcium ion transmembrane transport • transport • manganese ion transport • calcium ion transport • transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7220	22063
Ensembl	ENSG00000144935	ENSMUSG00000032839
UniProt	P48995	Q61056
RefSeq (mRNA)	NM_001251845 NM_003304	NM_011643 NM_001311123
RefSeq (protein)	NP_001238774 NP_003295	NP_001298052.1 NP_035773.1 NP_001298052 NP_035773
Location (UCSC)	Chr 3: 142.72 – 142.81 Mb	Chr 9: 95.71 – 95.75 Mb
PubMed search

7220

22063

ENSG00000144935

ENSMUSG00000032839

P48995

Q61056

NM_001251845
NM_003304

NM_011643
NM_001311123

NP_001238774
NP_003295

NP_001298052.1
NP_035773.1
NP_001298052
NP_035773

Transient receptor potential channel 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.

TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system. In HEK293 cells the unitary current-voltage relationship of endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV. The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.

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