TRIM28

TRIM28
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FP0, 2RO1, 2YVR
Identifiers
Aliases	TRIM28, KAP1, PPP1R157, RNF96, TF1B, TIF1B, tripartite motif containing 28
External IDs	MGI: 109274 HomoloGene: 21175 GeneCards: TRIM28
Gene ontology Molecular function • protein kinase activity • Krueppel-associated box domain binding • chromo shadow domain binding • transcription corepressor activity • promoter-specific chromatin binding • transcription coactivator activity • metal ion binding • ubiquitin-protein transferase activity • protein binding • ubiquitin protein ligase binding • transcription factor activity, sequence-specific DNA binding • RNA polymerase II transcription coactivator activity • sequence-specific DNA binding • DNA binding • chromatin binding • zinc ion binding • RNA binding • transferase activity Cellular component • nuclear euchromatin • intracellular • nuclear heterochromatin • chromatin • RNA polymerase II transcription factor complex • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • positive regulation of methylation-dependent chromatin silencing • convergent extension involved in axis elongation • embryonic placenta morphogenesis • positive regulation of DNA repair • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription factor import into nucleus • negative regulation of viral release from host cell • negative regulation of DNA demethylation • protein phosphorylation • protein oligomerization • protein autophosphorylation • DNA methylation involved in embryo development • Ras protein signal transduction • transcription initiation from RNA polymerase II promoter • DNA repair • embryo implantation • positive regulation of transcription from RNA polymerase II promoter • regulation of genetic imprinting • protein sumoylation • epithelial to mesenchymal transition • protein ubiquitination • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • covalent chromatin modification • positive regulation of DNA binding • innate immune response • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10155	21849
Ensembl	ENSG00000130726	ENSMUSG00000005566
UniProt	Q13263	Q62318
RefSeq (mRNA)	NM_005762	NM_011588
RefSeq (protein)	NP_005753	NP_035718
Location (UCSC)	Chr 19: 58.54 – 58.55 Mb	Chr 7: 13 – 13.03 Mb
PubMed search

1FP0, 2RO1, 2YVR

10155

21849

ENSG00000130726

ENSMUSG00000005566

Q13263

Q62318

NM_005762

NM_011588

NP_005753

NP_035718

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene.

The protein encoded by this gene mediates transcriptional control by interaction with the Krüppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

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