TRIM21

TRIM21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IWG
Identifiers
Aliases	TRIM21, RNF81, RO52, Ro/SSA, SSA, SSA1, tripartite motif containing 21, Tripartite motif-containing protein 21
External IDs	MGI: 106657 HomoloGene: 2365 GeneCards: TRIM21
Gene ontology Molecular function • DNA binding • zinc ion binding • metal ion binding • protein binding • RNA binding • identical protein binding • ubiquitin-protein transferase activity • transferase activity Cellular component • cytoplasm • cytosol • SCF ubiquitin ligase complex • P-body • intracellular ribonucleoprotein complex • intracellular • autophagosome • cytoplasmic vesicle • nucleus • nucleoplasm Biological process • negative regulation of protein deubiquitination • response to interferon-gamma • positive regulation of autophagy • interferon-gamma-mediated signaling pathway • protein trimerization • positive regulation of viral entry into host cell • positive regulation of sequence-specific DNA binding transcription factor activity • protein monoubiquitination • regulation of type I interferon production • negative regulation of viral release from host cell • positive regulation of cell cycle • protein destabilization • protein ubiquitination • cell cycle • negative regulation of NF-kappaB transcription factor activity • protein autoubiquitination • negative regulation of viral transcription • innate immune response • protein polyubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6737	20821
Ensembl	ENSG00000132109	ENSMUSG00000030966
UniProt	P19474	Q62191
RefSeq (mRNA)	NM_003141	NM_001082552 NM_009277
RefSeq (protein)	NP_003132	n/a
Location (UCSC)	Chr 11: 4.38 – 4.39 Mb	Chr 7: 102.56 – 102.57 Mb
PubMed search

2IWG

6737

20821

ENSG00000132109

ENSMUSG00000030966

P19474

Q62191

NM_003141

NM_001082552
NM_009277

NP_003132

n/a

Tripartite motif-containing protein 21 also known as E3 ubiquitin-protein ligase TRIM21 is a protein that in humans is encoded by the TRIM21 gene. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. It is expressed in most human tissues.

TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING finger domain, a B-box type 1 and a B-box type 2 zinc finger, and a coiled coil region.

TRIM21 is an intracellular antibody effector in the intracellular antibody-mediated proteolysis pathway. It binds to immunoglobulin G as well as immunoglobulin M on antibody marked non-enveloped virions which have infected the cell. Either by autoubiquitination or by ubiquitination of a cofactor, it is then responsible for directing the virions to the proteasome. TRIM21 itself is not degraded in the proteasome unlike both the viral capsid and the bound antibody.

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Wikipedia