TREM1

TREM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q8M, 1SMO
Identifiers
Aliases	TREM1, CD354, TREM-1, triggering receptor expressed on myeloid cells 1
External IDs	MGI: 1930005 HomoloGene: 10243 GeneCards: TREM1
Gene ontology Molecular function • scaffold protein binding • receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • extracellular region • intracellular Biological process • intracellular signal transduction • neutrophil mediated killing of gram-negative bacterium • chemokine metabolic process • neutrophil chemotaxis • cytokine metabolic process • humoral immune response • regulation of immune response • cytokine secretion involved in immune response • innate immune response • neutrophil extravasation • cell migration • leukocyte migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54210	58217
Ensembl	ENSG00000124731	ENSMUSG00000042265
UniProt	Q9NP99	Q9JKE2
RefSeq (mRNA)	NM_001242589 NM_001242590 NM_018643	NM_021406 NM_001347399
RefSeq (protein)	NP_001229518 NP_001229519 NP_061113	NP_001334328 NP_067381
Location (UCSC)	Chr 6: 41.27 – 41.29 Mb	Chr 17: 48.23 – 48.25 Mb
PubMed search

1Q8M, 1SMO

54210

58217

ENSG00000124731

ENSMUSG00000042265

Q9NP99

Q9JKE2

NM_001242589
NM_001242590
NM_018643

NM_021406
NM_001347399

NP_001229518
NP_001229519
NP_061113

NP_001334328
NP_067381

Triggering receptor expressed on myeloid cells 1 is a protein that in humans is encoded by the TREM1 gene.

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM]

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