TRAF6

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1LB4, 1LB5, 1LB6, 2ECI, 2JMD, 3HCS, 3HCT, 3HCU, 4Z8M

Identifiers

Aliases

TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6

External IDs

OMIM: 602355 MGI: 108072 HomoloGene: 3395 GeneCards: TRAF6

Gene ontology
Molecular function	• protein N-terminus binding • histone deacetylase binding • ubiquitin protein ligase activity • metal ion binding • tumor necrosis factor receptor binding • mitogen-activated protein kinase kinase kinase binding • zinc ion binding • protein binding • thioesterase binding • ubiquitin conjugating enzyme binding • protein kinase binding • protein kinase B binding • ubiquitin-protein transferase activity • identical protein binding • ubiquitin protein ligase binding • transferase activity
Cellular component	• cytoplasm • cytosol • lipid droplet • perinuclear region of cytoplasm • cytoplasmic side of plasma membrane • nucleus • plasma membrane • protein complex • cell cortex • endosome membrane • CD40 receptor complex
Biological process	• positive regulation of transcription regulatory region DNA binding • response to interleukin-1 • toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • odontogenesis of dentin-containing tooth • positive regulation of interleukin-12 biosynthetic process • positive regulation of T cell activation • animal organ morphogenesis • T-helper 1 type immune response • toll-like receptor 9 signaling pathway • regulation of apoptotic process • ossification • regulation of immunoglobulin secretion • cytokine-mediated signaling pathway • osteoclast differentiation • positive regulation of osteoclast differentiation • stimulatory C-type lectin receptor signaling pathway • activation of NF-kappaB-inducing kinase activity • bone resorption • JNK cascade • membrane protein intracellular domain proteolysis • protein ubiquitination • positive regulation of T cell proliferation • I-kappaB kinase/NF-kappaB signaling • protein autoubiquitination • immune system process • positive regulation of JUN kinase activity • positive regulation of sequence-specific DNA binding transcription factor activity • protein polyubiquitination • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • positive regulation of interleukin-6 biosynthetic process • positive regulation of lipopolysaccharide-mediated signaling pathway • activation of MAPK activity • positive regulation of NF-kappaB transcription factor activity • positive regulation of interleukin-2 production • positive regulation of T cell cytokine production • immune response • negative regulation of transcription, DNA-templated • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of protein ubiquitination • positive regulation of smooth muscle cell proliferation • antigen processing and presentation of exogenous peptide antigen via MHC class II • cell development • protein complex assembly • protein K63-linked ubiquitination • myeloid dendritic cell differentiation • MyD88-dependent toll-like receptor signaling pathway • interleukin-1-mediated signaling pathway • neural tube closure • bone remodeling • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • cellular response to lipopolysaccharide • T cell receptor signaling pathway • activation of protein kinase activity • MyD88-independent toll-like receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter • signal transduction • cellular response to DNA damage stimulus • protein deubiquitination
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7189


22034

Ensembl


ENSG00000175104


ENSMUSG00000027164

UniProt


Q9Y4K3


P70196

RefSeq (mRNA)


NM_145803 NM_004620


NM_009424 NM_001303273

RefSeq (protein)


NP_004611 NP_665802


NP_001290202 NP_033450

Location (UCSC)

Chr 11: 36.49 – 36.51 Mb

Chr 2: 101.68 – 101.7 Mb

PubMed search

1LB4, 1LB5, 1LB6, 2ECI, 2JMD, 3HCS, 3HCT, 3HCU, 4Z8M

NM_009424
NM_001303273

NP_004611
NP_665802

NP_001290202
NP_033450

...
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