TRAF4

TRAF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EOD, 2YUC, 3ZJB, 4K8U, 4M4E
Identifiers
Aliases	TRAF4, CART1, MLN62, RNF83, TNF receptor associated factor 4
External IDs	MGI: 1202880 HomoloGene: 3173 GeneCards: TRAF4
Gene ontology Molecular function • DNA binding • zinc ion binding • metal ion binding • protein binding • WW domain binding • thioesterase binding • tumor necrosis factor receptor binding • protein kinase binding • ubiquitin protein ligase binding • identical protein binding Cellular component • cytoplasm • membrane • bicellular tight junction • plasma membrane • cell junction • perinuclear region of cytoplasm • cytoskeleton • nucleus • intracellular Biological process • regulation of apoptotic process • activation of NF-kappaB-inducing kinase activity • positive regulation of JNK cascade • positive regulation of protein homodimerization activity • respiratory gaseous exchange • multicellular organism development • respiratory tube development • signal transduction • positive regulation of protein kinase activity • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9618	22032
Ensembl	ENSG00000076604	ENSMUSG00000017386
UniProt	Q9BUZ4	Q61382
RefSeq (mRNA)	NM_004295 NM_145751	NM_009423
RefSeq (protein)	NP_004286	NP_033449.2 NP_033449
Location (UCSC)	Chr 17: 28.74 – 28.75 Mb	Chr 11: 78.16 – 78.17 Mb
PubMed search

2EOD, 2YUC, 3ZJB, 4K8U, 4M4E

9618

22032

ENSG00000076604

ENSMUSG00000017386

Q9BUZ4

Q61382

NM_004295
NM_145751

NM_009423

NP_004286

NP_033449.2
NP_033449

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins. TRAF proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-κB and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.

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Wikipedia