TRAF1

TRAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3M0D
Identifiers
Aliases	TRAF1, EBI6, MGC:10353, TNF receptor associated factor 1
External IDs	MGI: 101836 HomoloGene: 4138 GeneCards: TRAF1
Gene ontology Molecular function • thioesterase binding • tumor necrosis factor receptor binding • zinc ion binding • protein binding • ubiquitin protein ligase binding • identical protein binding Cellular component • cytoplasm • cytosol Biological process • regulation of apoptotic process • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • regulation of extrinsic apoptotic signaling pathway • signal transduction • protein complex assembly • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7185	22029
Ensembl	ENSG00000056558	ENSMUSG00000026875
UniProt	Q13077	P39428
RefSeq (mRNA)	NM_005658 NM_001190945 NM_001190947	NM_009421 NM_001326601
RefSeq (protein)	NP_001177874 NP_001177876 NP_005649	NP_033447.2 NP_001313530 NP_033447
Location (UCSC)	Chr 9: 120.9 – 120.93 Mb	Chr 2: 34.94 – 34.96 Mb
PubMed search

3M0D

7185

22029

ENSG00000056558

ENSMUSG00000026875

Q13077

P39428

NM_005658
NM_001190945
NM_001190947

NM_009421
NM_001326601

NP_001177874
NP_001177876
NP_005649

NP_033447.2
NP_001313530
NP_033447

TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. TRAF1 also functions as a negative regulator of inflammation by interfering with the linear ubiquitination of NEMO downstream of TLR signaling. This explains why TRAF1 polymorphisms cause an increased risk for rheumatic diseases.

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Wikipedia