TPH2

TPH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V06
Identifiers
Aliases	TPH2, ADHD7, NTPH, tryptophan hydroxylase 2
External IDs	MGI: 2651811 HomoloGene: 27831 GeneCards: TPH2
Gene ontology Molecular function • iron ion binding • metal ion binding • monooxygenase activity • tryptophan 5-monooxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen • oxidoreductase activity Cellular component • cytosol • neuron projection Biological process • cellular response to lithium ion • response to glucocorticoid • response to activity • indolalkylamine biosynthetic process • serotonin biosynthetic process • response to estrogen • response to calcium ion • aromatic amino acid family metabolic process • response to nutrient levels • circadian rhythm • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	121278	216343
Ensembl	ENSG00000139287	ENSMUSG00000006764
UniProt	Q8IWU9	Q8CGV2
RefSeq (mRNA)	NM_173353	NM_173391
RefSeq (protein)	NP_775489	NP_775567.2 NP_775567
Location (UCSC)	Chr 12: 71.94 – 72.19 Mb	Chr 10: 115.08 – 115.19 Mb
PubMed search

4V06

121278

216343

ENSG00000139287

ENSMUSG00000006764

Q8IWU9

Q8CGV2

NM_173353

NM_173391

NP_775489

NP_775567.2
NP_775567

Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain. Until the discovery of TPH2 in 2003, serotonin levels in the central nervous system were believed to be regulated by serotonin synthesis in peripheral tissues, in which tryptophan hydroxylase is the dominant form.

Tryptophan hydroxylase (TPH; EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility.[supplied by OMIM]

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