TPH1

TPH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MLW, 3HF6, 3HF8, 3HFB, 5J6D
Identifiers
Aliases	TPH1, TPRH, TRPH, tryptophan hydroxylase 1
External IDs	MGI: 98796 HomoloGene: 121565 GeneCards: TPH1
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.1 Start 18,017,564 bp End 18,042,426 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 30.43 cM Start 46,644,641 bp End 46,672,537 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • iron ion binding • metal ion binding • monooxygenase activity • tryptophan 5-monooxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen • oxidoreductase activity Cellular component • cytoplasm • cytosol • neuron projection Biological process • response to immobilization stress • mammary gland alveolus development • indolalkylamine biosynthetic process • serotonin biosynthetic process • negative regulation of ossification • aromatic amino acid family metabolic process • bone remodeling • circadian rhythm • positive regulation of fat cell differentiation • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7166	21990
Ensembl	ENSG00000129167	ENSMUSG00000040046
UniProt	P17752	P17532
RefSeq (mRNA)	NM_004179	NM_001136084 NM_001276372 NM_009414
RefSeq (protein)	NP_004170	NP_001129556 NP_001263301 NP_033440
Location (UCSC)	Chr 11: 18.02 – 18.04 Mb	Chr 11: 46.64 – 46.67 Mb
PubMed search

1MLW, 3HF6, 3HF8, 3HFB, 5J6D

7166

21990

ENSG00000129167

ENSMUSG00000040046

P17752

P17532

NM_004179

NM_001136084
NM_001276372
NM_009414

NP_004170

NP_001129556
NP_001263301
NP_033440

Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene.

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