TP73L

TP63

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4A9Z, 1RG6, 2RMN, 2Y9T, 2Y9U, 3QYM, 3QYN, 3US0, 3US1, 3US2, 3ZY0, 3ZY1

Identifiers

Aliases

TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein p63

External IDs

OMIM: 603273 MGI: 1330810 HomoloGene: 31189 GeneCards: TP63

Gene ontology
Molecular function	• protein domain specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription regulatory region DNA binding • metal ion binding • damaged DNA binding • protein binding • WW domain binding • double-stranded DNA binding • DNA binding • sequence-specific DNA binding • transcription factor activity, transcription factor binding • identical protein binding • chromatin binding • p53 binding • transcription factor activity, sequence-specific DNA binding • MDM2/MDM4 family protein binding
Cellular component	• cytoplasm • neuron projection • nucleus • rough endoplasmic reticulum • nuclear chromatin • transcription factor complex • nucleoplasm • protein complex • dendrite • mitochondrion • Golgi apparatus • cytosol
Biological process	• pattern specification process • skeletal system development • epithelial cell development • negative regulation of keratinocyte differentiation • epidermal cell division • anatomical structure formation involved in morphogenesis • prostate gland development • transcription from RNA polymerase II promoter • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development • ectoderm and mesoderm interaction • cellular response to DNA damage stimulus • female genitalia morphogenesis • odontogenesis of dentin-containing tooth • prostatic bud formation • cell aging • positive regulation of cell cycle G1/S phase transition • positive regulation of mesenchymal cell proliferation • spermatogenesis • multicellular organism aging • smooth muscle tissue development • positive regulation of fibroblast apoptotic process • animal organ morphogenesis • hair follicle morphogenesis • positive regulation of Notch signaling pathway • apoptotic process • chromatin remodeling • regulation of transcription, DNA-templated • regulation of neuron apoptotic process • positive regulation of apoptotic signaling pathway • regulation of cysteine-type endopeptidase activity involved in apoptotic process • transcription, DNA-templated • embryonic limb morphogenesis • negative regulation of mesoderm development • epidermis development • post-anal tail morphogenesis • response to gamma radiation • protein homotetramerization • Notch signaling pathway • hair follicle development • neuron apoptotic process • polarized epithelial cell differentiation • proximal/distal pattern formation • cell differentiation • positive regulation of keratinocyte proliferation • skin morphogenesis • epithelial cell differentiation • urinary bladder development • cellular response to UV • establishment of planar polarity • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • protein tetramerization • replicative cell aging • keratinocyte proliferation • positive regulation of osteoblast differentiation • regulation of epidermal cell division • negative regulation of transcription, DNA-templated • negative regulation of cellular senescence • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • sympathetic nervous system development • establishment of skin barrier • morphogenesis of a polarized epithelium • developmental process • keratinocyte differentiation • multicellular organism development • mitotic G1 DNA damage checkpoint • cloacal septation • response to X-ray • positive regulation of transcription from RNA polymerase II promoter • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • regulation of signal transduction by p53 class mediator • regulation of apoptotic process • aging • negative regulation of intracellular estrogen receptor signaling pathway • positive regulation of transcription, DNA-templated • positive regulation of somatic stem cell population maintenance
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8626


22061

Ensembl


ENSG00000073282


ENSMUSG00000022510

UniProt


Q9H3D4


O88898

RefSeq (mRNA)

NM_001114978 NM_001114979 NM_001114980 NM_001114981 NM_001114982
NM_003722 NM_001329144 NM_001329145 NM_001329146 NM_001329148 NM_001329149 NM_001329150 NM_001329964

NM_001127259 NM_001127260 NM_001127261 NM_001127262 NM_001127263
NM_001127264 NM_001127265 NM_011641

RefSeq (protein)

NP_001108450 NP_001108451 NP_001108452 NP_001108453 NP_001108454
NP_001316073 NP_001316074 NP_001316075 NP_001316077 NP_001316078 NP_001316079 NP_001316893 NP_003713

NP_001120731 NP_001120732 NP_001120733 NP_001120734 NP_001120735
NP_001120736 NP_001120737 NP_035771

Location (UCSC)

Chr 3: 189.63 – 189.9 Mb

Chr 16: 25.68 – 25.89 Mb

PubMed search

4A9Z, 1RG6, 2RMN, 2Y9T, 2Y9U, 3QYM, 3QYN, 3US0, 3US1, 3US2, 3ZY0, 3ZY1

NM_003722
NM_001329144
NM_001329145
NM_001329146
NM_001329148
NM_001329149
NM_001329150
NM_001329964

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