TP53BP1

TP53BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG
Identifiers
Aliases	TP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 1
External IDs	MGI: 1351320 HomoloGene: 4137 GeneCards: TP53BP1
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription cofactor activity • p53 binding • RNA polymerase II activating transcription factor binding • methylated histone binding • protein binding • ubiquitinated histone binding Cellular component • cytoplasm • condensed chromosome kinetochore • nucleoplasm • chromosome • chromosome, telomeric region • chromosome, centromeric region • kinetochore • nuclear body • nucleus • site of double-strand break Biological process • regulation of transcription, DNA-templated • cellular response to X-ray • DNA damage checkpoint • positive regulation of sequence-specific DNA binding transcription factor activity • protein sumoylation • transcription, DNA-templated • cellular response to DNA damage stimulus • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • DNA repair • double-strand break repair via nonhomologous end joining • positive regulation of isotype switching • protein homooligomerization • negative regulation of double-strand break repair via homologous recombination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7158	27223
Ensembl	ENSG00000067369	ENSMUSG00000043909
UniProt	Q12888	P70399
RefSeq (mRNA)	NM_001141979 NM_001141980 NM_005657	NM_001290830 NM_013735
RefSeq (protein)	NP_001135451 NP_001135452 NP_005648	NP_001277759.1 NP_038763.3 NP_001277759 NP_038763
Location (UCSC)	Chr 15: 43.4 – 43.51 Mb	Chr 2: 121.19 – 121.27 Mb
PubMed search

1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG

7158

27223

ENSG00000067369

ENSMUSG00000043909

Q12888

P70399

NM_001141979
NM_001141980
NM_005657

...
Wikipedia