TNF-Related Apoptosis Induced Ligand

TNFSF10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D0G, 1D2Q, 1D4V, 1DG6, 1DU3, 4N90
Identifiers
Aliases	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A, tumor necrosis factor superfamily member 10, TNF superfamily member 10
External IDs	OMIM: 603598 MGI: 107414 HomoloGene: 2824 GeneCards: TNFSF10
Gene ontology Molecular function • cytokine activity • metal ion binding • protein binding • tumor necrosis factor receptor superfamily binding • tumor necrosis factor receptor binding • receptor binding Cellular component • integral component of membrane • membrane • integral component of plasma membrane • extracellular region • extracellular exosome • extracellular space Biological process • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • cell-cell signaling • cell surface receptor signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of release of cytochrome c from mitochondria • positive regulation of extrinsic apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway via death domain receptors • activation of cysteine-type endopeptidase activity involved in apoptotic process • signal transduction • apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of apoptotic process • male gonad development • response to insulin Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8743	22035
Ensembl	ENSG00000121858	ENSMUSG00000039304
UniProt	P50591	P50592
RefSeq (mRNA)	NM_001190942 NM_001190943 NM_003810	NM_009425
RefSeq (protein)	NP_001177871 NP_001177872 NP_003801	NP_033451
Location (UCSC)	Chr 3: 172.51 – 172.52 Mb	Chr 3: 27.32 – 27.34 Mb
PubMed search

1D0G, 1D2Q, 1D4V, 1DG6, 1DU3, 4N90

8743

22035

ENSG00000121858

ENSMUSG00000039304

P50591

P50592

NM_001190942
NM_001190943
NM_003810

NM_009425

NP_001177871
NP_001177872
NP_003801

NP_033451

In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis.

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Wikipedia