TNF-α

tumor necrosis factor
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW
Identifiers
Aliases	TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, Tumour necrosis factor alpha, TNF-α
External IDs	MGI: 104798 HomoloGene: 496 GeneCards: TNF
Gene ontology Molecular function • transcription regulatory region DNA binding • protein binding • identical protein binding • protease binding • tumor necrosis factor receptor binding • cytokine activity Cellular component • membrane • cell surface • integral component of membrane • recycling endosome • intracellular • integral component of plasma membrane • phagocytic cup • external side of plasma membrane • extracellular region • plasma membrane • membrane raft • Biological process • regulation of protein phosphorylation • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • response to salt stress • positive regulation of calcidiol 1-monooxygenase activity • positive regulation of programmed cell death • positive regulation of JNK cascade • response to organic substance • negative regulation of osteoblast differentiation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of viral genome replication • humoral immune response • positive regulation of interleukin-8 production • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of protein localization to cell surface • positive regulation of ERK1 and ERK2 cascade • glucose metabolic process • animal organ morphogenesis • apoptotic signaling pathway • negative regulation of alkaline phosphatase activity • regulation of I-kappaB kinase/NF-kappaB signaling • defense response to Gram-positive bacterium • regulation of branching involved in salivary gland morphogenesis • positive regulation of phagocytosis • negative regulation of fat cell differentiation • negative regulation of myoblast differentiation • positive regulation of protein kinase B signaling • regulation of insulin secretion • regulation of immunoglobulin secretion • osteoclast differentiation • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of cytokine secretion • response to virus • positive regulation of osteoclast differentiation • negative regulation of cytokine secretion involved in immune response • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • negative regulation of branching involved in lung morphogenesis • JNK cascade • death-inducing signaling complex assembly • regulation of osteoclast differentiation • defense response to bacterium • positive regulation of interleukin-6 production • positive regulation of interleukin-8 biosynthetic process • I-kappaB kinase/NF-kappaB signaling • activation of MAPKKK activity • positive regulation of translational initiation by iron • sequestering of triglyceride • positive regulation of chronic inflammatory response to antigenic stimulus • positive regulation of heterotypic cell-cell adhesion • negative regulation of growth of symbiont in host • positive regulation of chemokine (C-X-C motif) ligand 2 production • positive regulation of JUN kinase activity • positive regulation of hair follicle development • chronic inflammatory response to antigenic stimulus • cellular response to organic cyclic compound • positive regulation of fever generation • extracellular matrix organization • positive regulation of sequence-specific DNA binding transcription factor activity • cellular response to nicotine • positive regulation of podosome assembly • regulation of reactive oxygen species metabolic process • positive regulation of protein transport • negative regulation of glucose import • receptor biosynthetic process • activation of MAPK activity • immune response • positive regulation of NFAT protein import into nucleus • leukocyte tethering or rolling • positive regulation of chemokine production • cellular extravasation • negative regulation of lipid storage • negative regulation of myosin-light-chain-phosphatase activity • negative regulation of transcription, DNA-templated • cortical actin cytoskeleton organization • embryonic digestive tract development • leukocyte migration • lipopolysaccharide-mediated signaling pathway • positive regulation of smooth muscle cell proliferation • positive regulation of protein kinase activity • positive regulation of superoxide dismutase activity • defense response • positive regulation of ceramide biosynthetic process • positive regulation of protein complex assembly • protein kinase B signaling • positive regulation of cytokine production • positive regulation of chemokine biosynthetic process • epithelial cell proliferation involved in salivary gland morphogenesis • positive regulation of nitric oxide biosynthetic process • negative regulation of interleukin-6 production • protein import into nucleus, translocation • positive regulation of membrane protein ectodomain proteolysis • positive regulation of humoral immune response mediated by circulating immunoglobulin • positive regulation of interferon-gamma production • response to glucocorticoid • positive regulation of vitamin D biosynthetic process • positive regulation of mononuclear cell migration • positive regulation of NIK/NF-kappaB signaling • MAPK cascade • negative regulation of protein complex disassembly • multicellular organism development • negative regulation of bicellular tight junction assembly • positive regulation of protein complex disassembly • regulation of cell proliferation • cellular response to amino acid stimulus • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • cellular response to lipopolysaccharide • negative regulation of lipid catabolic process • regulation of establishment of endothelial barrier • positive regulation of cell adhesion • establishment of protein localization to plasma membrane • regulation of protein secretion • positive regulation of apoptotic process • inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • tumor necrosis factor-mediated signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • necroptotic signaling pathway • positive regulation of gene expression • extrinsic apoptotic signaling pathway • extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of transcription from RNA polymerase II promoter • positive regulation of NF-kappaB transcription factor activity • positive regulation of NF-kappaB import into nucleus • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of leukocyte adhesion to arterial endothelial cell • positive regulation of leukocyte adhesion to vascular endothelial cell • positive regulation of blood microparticle formation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7124	21926
Ensembl	n/a	ENSMUSG00000024401
UniProt	P01375	P06804
RefSeq (mRNA)	NM_000594	NM_001278601 NM_013693
RefSeq (protein)	NP_000585	NP_001265530.1 NP_038721.1 NP_001265530 NP_038721
Location (UCSC)	Chr 6: 31.58 – 31.58 Mb	Chr 17: 35.2 – 35.2 Mb
PubMed search

1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW

7124

21926

n/a

ENSMUSG00000024401

P01375

P06804

NM_000594

NM_001278601
NM_013693

...
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