TMPRSS2

TMPRSS2
Identifiers
Aliases	TMPRSS2, PP9284, PRSS10, transmembrane protease, serine 2
External IDs	MGI: 1354381 HomoloGene: 4136 GeneCards: TMPRSS2
Gene ontology Molecular function • scavenger receptor activity • peptidase activity • serine-type peptidase activity • protein binding • hydrolase activity • serine-type endopeptidase activity Cellular component • integral component of membrane • extracellular region • plasma membrane • integral component of plasma membrane • extracellular exosome • membrane Biological process • positive regulation of viral entry into host cell • protein autoprocessing • receptor-mediated endocytosis • proteolysis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7113	50528
Ensembl	ENSG00000184012	ENSMUSG00000000385
UniProt	O15393	Q9JIQ8
RefSeq (mRNA)	NM_001135099 NM_005656	NM_015775
RefSeq (protein)	NP_001128571 NP_005647	NP_056590.2 NP_056590
Location (UCSC)	Chr 21: 41.46 – 41.53 Mb	Chr 16: 97.56 – 97.61 Mb
PubMed search

7113

50528

ENSG00000184012

ENSMUSG00000000385

O15393

Q9JIQ8

NM_001135099
NM_005656

NM_015775

NP_001128571
NP_005647

NP_056590.2
NP_056590

Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene.

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. The biological function of this gene is unknown.

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Wikipedia