TMC2

TMC2
Identifiers
Aliases	TMC2, C20orf145, dJ686C3.3, transmembrane channel like 2
External IDs	MGI: 2151017 HomoloGene: 25877 GeneCards: TMC2
Genetically Related Diseases
obesity, systemic lupus erythematosus
Gene ontology Molecular function • voltage-gated calcium channel activity • mechanically-gated ion channel activity Cellular component • membrane • stereocilium tip • integral component of membrane Biological process • ion transport • detection of mechanical stimulus involved in sensory perception of sound • vestibular reflex • calcium ion transmembrane transport • transport • regulation of calcium ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	117532	192140
Ensembl	ENSG00000149488	ENSMUSG00000060332
UniProt	Q8TDI7	Q8R4P4
RefSeq (mRNA)	NM_080751	NM_138655
RefSeq (protein)	NP_542789	NP_619596.1 NP_619596
Location (UCSC)	Chr 20: 2.54 – 2.64 Mb	Chr 2: 130.2 – 130.26 Mb
PubMed search

117532

192140

ENSG00000149488

ENSMUSG00000060332

Q8TDI7

Q8R4P4

NM_080751

NM_138655

NP_542789

NP_619596.1
NP_619596

Transmembrane channel-like protein 2 is a protein that in humans is encoded by the TMC2 gene.

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function.

Mutations in this gene may underlie hereditary disorders of balance and hearing.

...
Wikipedia