TLR8

TLR8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N, 3WN4, 4QBZ, 4QC0, 4R07, 4R08, 4R09, 4R0A, 4R6A, 5AWB, 5AWD, 5HDH, 5AWA
Identifiers
Aliases	TLR8, CD288, toll like receptor 8
External IDs	MGI: 2176887 HomoloGene: 44054 GeneCards: TLR8
Targeted by Drug
resiquimod
Gene ontology Molecular function • DNA binding • single-stranded RNA binding • drug binding • RNA binding • double-stranded RNA binding • receptor activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • Golgi membrane • endolysosome membrane • endosome membrane • integral component of plasma membrane Biological process • regulation of protein phosphorylation • immune system process • positive regulation of interferon-gamma biosynthetic process • regulation of cytokine secretion • positive regulation of interferon-beta biosynthetic process • response to virus • MyD88-dependent toll-like receptor signaling pathway • microglial cell activation • cellular response to mechanical stimulus • defense response to virus • immunoglobulin mediated immune response • positive regulation of innate immune response • positive regulation of interleukin-8 biosynthetic process • toll-like receptor 9 signaling pathway • positive regulation of interferon-alpha biosynthetic process • toll-like receptor 8 signaling pathway • I-kappaB kinase/NF-kappaB signaling • signal transduction • toll-like receptor signaling pathway • innate immune response • inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51311	170744
Ensembl	ENSG00000101916	ENSMUSG00000040522
UniProt	Q9NR97	P58682
RefSeq (mRNA)	NM_016610 NM_138636	NM_133212 NM_001313760 NM_001313761
RefSeq (protein)	NP_057694 NP_619542	NP_001300689.1 NP_001300690.1 NP_573475.2 NP_001300689 NP_001300690 NP_573475
Location (UCSC)	Chr X: 12.91 – 12.92 Mb	Chr X: 167.24 – 167.26 Mb
PubMed search

3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N, 3WN4, 4QBZ, 4QC0, 4R07, 4R08, 4R09, 4R0A, 4R6A, 5AWB, 5AWD, 5HDH, 5AWA

51311

170744

ENSG00000101916

ENSMUSG00000040522

Q9NR97

P58682

...
Wikipedia