TLR7

TLR7
Identifiers
Aliases	TLR7, TLR7-like, toll like receptor 7
External IDs	OMIM: 300365 MGI: 2176882 HomoloGene: 75060 GeneCards: TLR7
Targeted by Drug
imiquimod, resiquimod, hydroxychloroquine
Gene ontology Molecular function • transmembrane signaling receptor activity • double-stranded RNA binding • drug binding • siRNA binding • single-stranded RNA binding Cellular component • integral component of membrane • Golgi membrane • cytoplasmic vesicle • early phagosome • endosome • receptor complex • phagocytic vesicle • membrane • lysosome • endoplasmic reticulum • plasma membrane • endolysosome membrane • cytoplasm • endosome membrane • endoplasmic reticulum membrane Biological process • I-kappaB phosphorylation • immune system process • positive regulation of inflammatory response • positive regulation of interleukin-8 biosynthetic process • toll-like receptor 9 signaling pathway • positive regulation of NF-kappaB import into nucleus • positive regulation of interleukin-8 production • toll-like receptor signaling pathway • regulation of protein phosphorylation • defense response to virus • positive regulation of interferon-alpha biosynthetic process • cellular response to mechanical stimulus • microglial cell activation • positive regulation of interferon-beta biosynthetic process • positive regulation of interleukin-6 production • MyD88-dependent toll-like receptor signaling pathway • signal transduction • positive regulation of chemokine production • positive regulation of interferon-gamma biosynthetic process • immune response • toll-like receptor 7 signaling pathway • innate immune response • inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51284	170743
Ensembl	ENSG00000196664	ENSMUSG00000044583
UniProt	Q9NYK1	P58681
RefSeq (mRNA)	NM_016562	NM_133211 NM_001290755 NM_001290756 NM_001290757 NM_001290758
RefSeq (protein)	NP_057646	NP_001277684.1 NP_001277685.1 NP_001277686.1 NP_573474.1 NP_001277684 NP_001277685 NP_001277686 NP_001277687 NP_573474
Location (UCSC)	Chr X: 12.87 – 12.89 Mb	Chr X: 167.3 – 167.33 Mb
PubMed search

51284

170743

ENSG00000196664

ENSMUSG00000044583

Q9NYK1

P58681

NM_016562

NM_133211
NM_001290755
NM_001290756
NM_001290757
NM_001290758

NP_057646

NP_001277685
NP_001277686
NP_001277687
NP_573474

Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. It is a member of the toll-like receptor (TLR) family and detects single stranded RNA.

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Wikipedia