TLR5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3J0A

Identifiers

Aliases

TLR5, MELIOS, SLE1, SLEB1, TIL3, toll like receptor 5

External IDs

OMIM: 603031 MGI: 1858171 HomoloGene: 20698 GeneCards: TLR5

Gene ontology
Molecular function	• transmembrane signaling receptor activity • interleukin-1 receptor binding
Cellular component	• integral component of membrane • membrane • plasma membrane
Biological process	• positive regulation of cytokine production • signal transduction • positive regulation of nitric oxide biosynthetic process • cellular response to lipopolysaccharide • positive regulation of toll-like receptor signaling pathway • defense response to bacterium • MyD88-dependent toll-like receptor signaling pathway • regulation of cytokine secretion • toll-like receptor 5 signaling pathway • immune system process • positive regulation of interleukin-8 production • male gonad development • cellular response to mechanical stimulus • innate immune response • inflammatory response
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7100


53791

Ensembl


ENSG00000187554


ENSMUSG00000079164

UniProt


O60602


Q9JLF7

RefSeq (mRNA)


NM_003268


NM_016928

RefSeq (protein)


NP_003259


NP_058624.2 NP_058624

Location (UCSC)

Chr 1: 223.11 – 223.14 Mb

Chr 1: 182.95 – 182.98 Mb

PubMed search

NP_058624.2
NP_058624

Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. It is a member of the toll-like receptor (TLR) family. TLR5 is known to recognize bacterial flagellin from invading mobile bacteria. Its has been shown to be involved in the onset of many diseases, which includes Inflammatory bowel disease. Recent studies have also shown that malfunctioning of TLR5 is likely related to osteoclastogenesis and bone loss. Abnormal TLR5 functioning is related to the onset of gastric, cervical, endometrial and ovarian cancers.

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Wikipedia