TLR3

TLR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Identifiers
Aliases	TLR3, CD283, IIAE2, toll like receptor 3
External IDs	OMIM: 603029 MGI: 2156367 HomoloGene: 20696 GeneCards: TLR3
Gene ontology Molecular function • protein binding • identical protein binding • RNA binding • double-stranded RNA binding • transmembrane signaling receptor activity • receptor activity Cellular component • cytoplasm • integral component of membrane • endosome • endoplasmic reticulum membrane • membrane • Golgi membrane • integral component of plasma membrane • intracellular • cell surface • lysosomal membrane • early endosome • endoplasmic reticulum • endolysosome membrane • endosome membrane Biological process • positive regulation of interferon-beta production • response to dsRNA • defense response • positive regulation of toll-like receptor signaling pathway • positive regulation of protein phosphorylation • male gonad development • positive regulation of inflammatory response • positive regulation of interleukin-12 production • positive regulation of type III interferon production • cellular response to interferon-beta • response to exogenous dsRNA • positive regulation of chemokine biosynthetic process • positive regulation of interferon-gamma biosynthetic process • negative regulation of osteoclast differentiation • positive regulation of cytokine production • positive regulation of interferon-beta biosynthetic process • immune system process • response to virus • activation of NF-kappaB-inducing kinase activity • I-kappaB phosphorylation • positive regulation of JNK cascade • hyperosmotic response • cellular response to dsRNA • regulation of dendritic cell cytokine production • microglial cell activation • toll-like receptor signaling pathway • TRIF-dependent toll-like receptor signaling pathway • cellular response to mechanical stimulus • microglial cell activation involved in immune response • cellular response to drug • positive regulation of gene expression • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • defense response to virus • necroptotic signaling pathway • positive regulation of interleukin-8 production • cellular response to exogenous dsRNA • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • cellular response to interferon-gamma • positive regulation of chemokine production • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of interferon-alpha biosynthetic process • positive regulation of NF-kappaB import into nucleus • detection of virus • inflammatory response • innate immune response • I-kappaB kinase/NF-kappaB signaling • toll-like receptor 3 signaling pathway • positive regulation of type I interferon production • MyD88-independent toll-like receptor signaling pathway • signal transduction • positive regulation of transcription from RNA polymerase II promoter • necroptotic process • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway • extrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7098	142980
Ensembl	ENSG00000164342	ENSMUSG00000031639
UniProt	O15455	Q99MB1
RefSeq (mRNA)	NM_003265	NM_126166
RefSeq (protein)	NP_003256	NP_569054.2 NP_569054
Location (UCSC)	Chr 4: 186.07 – 186.09 Mb	Chr 8: 45.4 – 45.41 Mb
PubMed search

1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA

7098

142980

ENSG00000164342

ENSMUSG00000031639

O15455

Q99MB1

NM_003265

NM_126166

NP_003256

NP_569054.2
NP_569054

Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. TLR3 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system.

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Wikipedia